Decreased plasma levels of soluble receptor for advanced glycation end-products in patients with essential hypertension

被引:169
作者
Geroldi, D
Falcone, C
Emanuele, E
D'Angelo, A
Calcagnino, M
Buzzi, MP
Scioli, GA
Fogari, R
机构
[1] Univ Pavia, IRCCS, San Matteo Hosp, Dept Internal Med & Med Therapeut, I-27100 Pavia, Italy
[2] Univ Pavia, IRCCS, San Matteo Hosp, Interdept Ctr Res Mol Med, I-27100 Pavia, Italy
[3] Univ Pavia, IRCCS, San Matteo Hosp, Dept Cardiol, I-27100 Pavia, Italy
[4] F Veneziale Hosp Isernia, Ctr Prevent Cardiovasc Dis, Isernia, Italy
关键词
arterial stiffening; enzyme-linked immunosorbent assay; hypertension; pulse pressure; soluble receptor for advanced glycation and products;
D O I
10.1097/01.hjh.0000177535.45785.64
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Objectives Advanced glycation end-products (AGE) may cause vascular stiffening by forming crosslinks through the collagen molecule or by interaction with their cellular transductional receptor (RAGE). A secreted isoform of RAGE, termed soluble RAGE (sRAGE), may contribute to the removal/detoxification of AGE by acting as a decoy. Here we studied the plasma sRAGE levels in hypertensive and normotensive human subjects. We also investigated the relationship between blood pressure parameters and plasma sRAGE concentrations. Design A cross-sectional case-control study. Setting and participants The outpatient clinic of a university teaching hospital. Participants were 147 never-treated patients with essential hypertension (87 men and 60 women, aged 50 +/- 10 years) and 177 normotensive controls (118 men and 59 women, aged 49 +/- 10 years). Main outcome measures Plasma sRAGE levels determined by enzyme-linked immunosorbent assay, systolic blood pressure (SBP), diastolic blood pressure, pulse pressure (PP) and mean arterial pressure. Results The plasma concentration of sRAGE [median (interquartile range)] was 1206 (879-1658) pg/ml in hypertensive subjects and 1359 (999-2198) pg/ml in normotensive controls (P = 0.002). Simple correlation analysis revealed that log-transformed sRAGE levels were inversely correlated with SBP (r = -0.11; P < 0.001) and PP (r = -0.23; P < 0.001). Forward-selection multiple regression analysis revealed that log-transformed sRAGE levels were determined more strongly by PP (F = 3.127, P < 0.001). Conclusions Plasma sRAGE levels are decreased in patients with essential hypertension and are inversely related to PP. Our results raise the possibility that sRAGE may play a role in arterial stiffening and its complications. (c) 2005 Lippincott Williams & Wilkins.
引用
收藏
页码:1725 / 1729
页数:5
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