Life and Death of Lymphocytes: A Volume Regulation Affair

被引：18

作者：

Bortner, Carl D. ^{[1
]}

Cidlowski, John A. ^{[1
]}

机构：

[1] NIEHS, Lab Signal Transduct, NIH, US Dept HHS,NIH, Res Triangle Pk, NC 27709 USA

来源：

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY | 2011年 / 28卷 / 06期

关键词：

Cell Volume Regulation; Apoptotic Resistance; Osmotic stress; RVI; PLASMA-MEMBRANE DEPOLARIZATION; PROGRAMMED CELL-DEATH; INDUCED APOPTOSIS; PHYSIOLOGICAL CONCENTRATIONS; DEOXYRIBONUCLEIC-ACID; GLUTATHIONE DEPLETION; THYMOCYTE APOPTOSIS; SHRINKAGE NECROSIS; CHLORIDE CHANNELS; FLOW-CYTOMETRY;

D O I：

10.1159/000335864

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The loss of cell volume, termed apoptotic volume decrease (AVD) has been a hallmark feature of apoptosis. However the role of this characteristic attribute of programmed cell death has always been questioned as to whether it plays an active or passive factor during apoptosis. Here we review studies that suggest that AVD plays an active role during apoptosis and the underlying flux of ions that results in this morphological event regulates the programmed cell death process. Copyright (C) 2011 S. Karger AG, Basel

引用

页码：1079 / 1088

页数：10

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