Smart catheter flow sensor for real-time continuous regional cerebral blood flow monitoring

被引：19

作者：

Li, Chunyan ^{[1
]}

Wu, Pei-Ming ^{[1
]}

Hartings, Jed A. ^{[2
]}

Wu, Zhizhen ^{[3
]}

Ahn, Chong H. ^{[3
]}

LeDoux, David ^{[4
]}

Shutter, Lori A. ^{[2
]}

Narayan, Raj K. ^{[1
,5
]}

机构：

[1] Feinstein Inst Med Res, Cushing Neuromonitoring Lab, Manhasset, NY 11030 USA

[2] Univ Cincinnati, Coll Med, Dept Neurosurg, Cincinnati, OH 45219 USA

[3] Univ Cincinnati, Microsyst & BioMEMS Lab, Cincinnati, OH 45221 USA

[4] N Shore Univ Hosp, Neurosurg Intens Care Unit, Manhasset, NY 11030 USA

[5] Hofstra N Shore LIJ Sch Med, Dept Neurosurg, Hempstead, NY 11549 USA

来源：

APPLIED PHYSICS LETTERS | 2011年 / 99卷 / 23期

关键词：

BRAIN; TUBE;

D O I：

10.1063/1.3669705

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

We present a smart catheter flow sensor for real-time, continuous, and quantitative measurement of regional cerebral blood flow using in situ temperature and thermal conductivity compensation. The flow sensor operates in a constant-temperature mode and employs a periodic heating and cooling technique. This approach ensures zero drift and provides highly reliable data with microelectromechanical system-based thin film sensors. The developed flow sensor has a sensitivity of 0.973 mV/ml/100 g/min in the range from 0 to 160 ml/100 g/min with a linear correlation coefficient of R-2 = 0.9953. It achieves a resolution of 0.25 ml/100 g/min and an accuracy better than 5 ml/100 g/min. (C) 2011 American Institute of Physics. [doi:10.1063/1.3669705]

引用

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