pCEST: Positive contrast using Chemical Exchange Saturation Transfer

被引：17

作者：

Vinogradov, Elena ^{[2
]}

Soesbe, Todd C. ^{[1
]}

Balschi, James A. ^{[4
]}

Sherry, A. Dean ^{[1
,3
]}

Lenkinski, Robert E. ^{[2
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Adv Imaging Res Ctr, Dallas, TX 75390 USA

[2] Harvard Univ, Sch Med, Dept Radiol, Beth Israel Deaconess Med Ctr, Boston, MA 02115 USA

[3] Univ Texas Dallas, Dept Chem, Dallas, TX 75230 USA

[4] Harvard Univ, Brigham & Womens Hosp, Sch Med, Physiol NMR Core Lab, Boston, MA 02115 USA

来源：

JOURNAL OF MAGNETIC RESONANCE | 2012年 / 215卷

关键词：

CEST; PARACEST; Positive CEST; Off-resonance T-1 rho; OFF-RESONANCE IRRADIATION; MRI CONTRAST; IN-VIVO; MAGNETIZATION-TRANSFER; PARACEST AGENTS; LANTHANIDE COMPLEXES; CEST AGENT; RELAXATION; WATER; SIGNAL;

D O I：

10.1016/j.jmr.2011.12.011

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Chemical Exchange Saturation Transfer (CEST) contrast utilizes selective pre-saturation of a small pool of exchanging protons and subsequent detection of the decrease in bulk water signal. The CEST contrast is negative and requires detection of small signal change in the presence of a strong background signal. Here we develop a Positive CEST (pCEST) detection scheme utilizing the analogous nature of the CEST and off-resonance T-1 rho experiments and exploring increased apparent relaxation rates in the presence of the selective pre-saturation. pCEST leads to the positive contrast, i.e., increased signal intensity as the result of the presence of the agent and RF pre-saturation. Simultaneously substantial background suppression is achieved. The contrast can be switched "ON" and "OFF", similar to the original CEST. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：64 / 73

页数：10

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