Comparing the toxic mechanism of synthesized zinc oxide nanomaterials by physicochemical characterization and reactive oxygen species properties

被引:40
作者
Park, Soo Jin [1 ]
Park, Young Chan [2 ]
Lee, Sang Won [1 ]
Jeong, Min Sook [1 ]
Yu, Kyeong-Nam [2 ]
Jung, Haksung [3 ]
Lee, Jin-Kyu [3 ]
Kim, Jun Sung [1 ]
Cho, Myung-Haing [2 ,4 ,5 ,6 ]
机构
[1] Biterials Co Ltd, R&D Ctr, Seoul 140200, South Korea
[2] Seoul Natl Univ, Coll Vet Med, Toxicol Lab, Seoul 151742, South Korea
[3] Seoul Natl Univ, Coll Nat Sci, Dept Chem, Seoul 151742, South Korea
[4] Seoul Natl Univ, Grad Grp Tumor Biol, Seoul 151742, South Korea
[5] Seoul Natl Univ, Dept Nanofus Technol, Grad Sch Convergence Sci & Technol, Seoul 151742, South Korea
[6] Seoul Natl Univ, Adv Inst Convergence Technol, Suwon, South Korea
基金
新加坡国家研究基金会;
关键词
ZnO nanomaterials; Toxicity; Physicochemical characteristics; Reactive oxygen species; NANOCRYSTALLINE ZNO; OXIDATIVE STRESS; NANOPARTICLES;
D O I
10.1016/j.toxlet.2011.09.011
中图分类号
R99 [毒物学(毒理学)];
学科分类号
100405 ;
摘要
We studied the toxicity of ZnO nanomaterials in terms of physicochemical characteristics and reactive oxygen species (ROS) properties. ZnO nanorods [synthesized at room temperature (ZnO-RT, length; 18.0 +/- 4.2 nm) and at 60 degrees C (ZnO-60, length; 80.5 +/- 6.8 nm)] were used to evaluate the potential toxicity upon growth velocity-related particle size. The cytotoxicity of ZnO-60 was higher than that of ZnO-RT. We observed that the toxicity of ZnO-RT and ZnO-60 was related with ROS formation by using antioxidant N-acetylcysteine and electron spin resonance. Also, we found that the source of toxicity was not related to Zn2+ ions released from ZnO in 24 h treatment. Our results indicate that toxicity of ZnO nanorods is caused by the amounts of ROS. Our study strongly suggests that size of nanomaterial is not the sole factor to be considered, thus, the development of appropriate criteria based on morphological/physicochemical characteristics as well as synthesis procedures is needed to evaluate the precise toxicity. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:197 / 203
页数:7
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