Association between CYP2D6 phenotype and recurrence of Plasmodium vivax infection in south Korean patients

被引：5

作者：

Choi, Sungim ^{[1
]}

Choi, Heun ^{[2
]}

Park, Seong Yeon ^{[1
]}

Kwak, Yee Gyung ^{[3
]}

Song, Je Eun ^{[3
]}

Shin, So Youn ^{[4
]}

Baek, Ji Hyeon ^{[5
]}

Shin, Hyun-Il ^{[6
]}

Cho, Shin-Hyung ^{[6
]}

Lee, Sang-Eun ^{[6
]}

Kwon, Jeong-Ran ^{[7
]}

Park, Sookkyung ^{[7
]}

Kim, Miyoung ^{[7
]}

Oh, Hong Sang ^{[8
]}

Kim, Yong Chan ^{[9
]}

Kim, Min Jae ^{[10
]}

Yeom, Joon-Sup ^{[11
]}

机构：

[1] Dongguk Univ, Dept Internal Med, Div Infect Dis, Ilsan Hosp, Goyang Si, Gyeonggi Do, South Korea

[2] Natl Hlth Insurance Serv Ilsan Hosp, Dept Infect Dis, Goyang Si, Gyeonggi Do, South Korea

[3] Inje Univ, Dept Internal Med, Div Infect Dis, Ilsan Paik Hosp, Goyang Si, Gyeonggi Do, South Korea

[4] Catholic Kwandong Univ, Dept Internal Med, Coll Med, Int St Marys Hosp, Incheon, South Korea

[5] Inha Univ, Dept Internal Med, Coll Med, Incheon, South Korea

[6] Korea Dis Control & Prevent Agcy, Div Vectors & Parasit Dis, Bur Infect Dis Diag Control, Chungcheongbuk Do, South Korea

[7] Korea Dis Control & Prevent Agcy, Div Zoonot & Vector Borne Dis Control, Bur Infect Dis Policy, Chungcheongbuk Do, South Korea

[8] Armed Forces Capital Hosp, Dept Internal Med, Seongnam Si, Gyeonggi Do, South Korea

[9] Yonsei Univ, Yongin Severance Hosp, Dept Internal Med, Div Infect Dis,Coll Med, Yongin, South Korea

[10] Univ Ulsan, Asan Med Ctr, Dept Infect Dis, Coll Med, Seoul, South Korea

[11] Yonsei Univ, Severance Hosp, Dept Internal Med, Div Infect Dis,Coll Med, Seoul, South Korea

来源：

MALARIA JOURNAL | 2022年 / 21卷 / 01期

关键词：

Primaquine; Relapse; Plasmodium vivax; MALARIA; POLYMORPHISMS;

D O I：

10.1186/s12936-022-04311-6

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Background Primaquine is activated by CYP2D6 in the hepatocytes. In Korea, primaquine is the only hypnozoitocidal agent used for patients with vivax malaria. Thus, patients with poor CYP2D6 activity could have an increased risk of primaquine failure and subsequent relapse. The study sought to identify the association between CYP2D6 phenotype and recurrence of malaria in Korean patients. Methods A total of 102 patients with vivax malaria were prospectively enrolled from eight institutions in Korea. An additional 38 blood samples from patients with recurred vivax malaria were provided by the Korea Disease Control and Prevention Agency. Malaria recurrence was defined as more than one episode of vivax malaria in the same or consecutive years. CYP2D6 star alleles, phenotypes, and activity scores were examined. Results Genotyping for CYP2D6 was successful in 101 of the prospectively enrolled patients and 38 samples from the Korea Disease Control and Prevention Agency, of which 91 were included in the no-recurrence group and 48 were included in the recurrence group. Reduced CYP2D6 activity (intermediate metabolizer) phenotype was more common in the recurrence group than in the no-recurrence group (OR, 2.33 (95% CI, 1.14-4.77); p = 0.02). Patients with lower CYP2D6 activity had a higher probability of recurrence (p = 0.029). Conclusion This study suggests that CYP2D6 polymorphism may affect primaquine efficacy and thus Plasmodium vivax recurrence in Korea.

引用

页数：8

共 26 条

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