Ketogenic Diet and Epilepsy: What We Know So Far

被引：224

作者：

Meira, Isabella D'Andrea ^{[1
,2
]}

Romao, Tayla Taynan ^{[2
]}

Pires do Prado, Henrique Jannuzzelli ^{[1
,2
]}

Kruger, Lia Theophilo ^{[1
]}

Paiva Pires, Maria Elisa ^{[1
]}

da Conceicao, Priscila Oliveira ^{[3
]}

机构：

[1] Paulo Niemeyer State Brain Inst, Epilepsy Dept, Rio De Janeiro, Brazil

[2] Fed Fluminense Univ, Neurol Dept, Rio De Janeiro, Brazil

[3] Univ Estado Rio De Janeiro, Neurol Dept, Rio De Janeiro, Brazil

来源：

FRONTIERS IN NEUROSCIENCE | 2019年 / 13卷

关键词：

refractory epilepsy; ketogenic diet; modified Atkins diet; low glycemic index; diet therapy; MODIFIED ATKINS DIET; GLYCEMIC-INDEX TREATMENT; ANTICONVULSANT MECHANISM; INTRACTABLE EPILEPSY; REFRACTORY EPILEPSY; ADULTS; MANAGEMENT; EFFICACY; SEIZURES; NEURONS;

D O I：

10.3389/fnins.2019.00005

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The Ketogenic Diet (KD) is a modality of treatment used since the 1920s as a treatment for intractable epilepsy. It has been proposed as a dietary treatment that would produce similar benefits to fasting, which is already recorded in the Hippocratic collection. The KD has a high fat content (90%) and low protein and carbohydrate. Evidence shows that KD and its variants are a good alternative for non-surgical pharmacoresistant patients with epilepsy of any age, taking into account that the type of diet should be designed individually and that less-restrictive and more-palatable diets are usually better options for adults and adolescents. This review discusses the KD, including the possible mechanisms of action, applicability, side effects, and evidence for its efficacy, and for the more-palatable diets such as the Modified Atkins Diet (MAD) and the Low Glycemic Index Diet (LGID) in children and adults.

引用

页数：8

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