Transcriptional regulation of cellular senescence

被引：74

作者：

Lanigan, F. ^{[1
]}

Geraghty, J. G. ^{[3
]}

Bracken, A. P. ^{[1
,2
]}

机构：

[1] Trinity Coll Dublin, Smurfit Genet Dept, Smurfit Inst Genet, Dublin 2, Ireland

[2] Natl Childrens Hosp, Adelaide & Meath Hosp, Dublin, Ireland

[3] Univ Coll Dublin, St Vincents Hosp, Dept Breast & Endocrine Surg, Dublin 2, Ireland

来源：

ONCOGENE | 2011年 / 30卷 / 26期

基金：

爱尔兰科学基金会;

关键词：

cellular senescence; transcription; cancer therapy; ONCOGENE-INDUCED SENESCENCE; INK4A TUMOR-SUPPRESSOR; DEMETHYLASE JMJD3 CONTRIBUTES; INDUCED PREMATURE SENESCENCE; E2F TARGET GENES; HISTONE DEACETYLASE; RETINOBLASTOMA PROTEIN; HUMAN FIBROBLASTS; CANCER-THERAPY; IN-VIVO;

D O I：

10.1038/onc.2011.34

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cellular senescence is an irreversible arrest of proliferation. It is activated when a cell encounters stress such as DNA damage, telomere shortening or oncogene activation. Like apoptosis, it impedes tumour progression and acts as a barrier that pre-neoplastic cells must overcome during their evolution toward the full tumourigenic state. This review focuses on the role of transcriptional regulators in the control of cellular senescence, explores how their function is perturbed in cancer and discusses the potential to harness this knowledge for future cancer therapies. Oncogene (2011) 30, 2901-2911; doi:10.1038/onc.2011.34; published online 7 March 2011

引用

页码：2901 / 2911

页数：11

共 149 条

[1] The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence [J].

Agger, Karl ;

Cloos, Paul A. C. ;

Rudkjaer, Lise ;

Williams, Kristine ;

Andersen, Gitte ;

Christensen, Jesper ;

Helin, Kristian .

GENES & DEVELOPMENT, 2009, 23 (10) :1171-1176

[2] Id1 regulation of cellular senescence through transcriptional repression of p16/Ink4a [J].

Alani, RM ;

Young, AZ ;

Shifflett, CB .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (14) :7812-7816

[3] Repression of the Arf tumor suppressor by E2F3 is required for normal cell cycle kinetics [J].

Aslanian, A ;

Iaquinta, PJ ;

Verona, R ;

Lees, JA .

GENES & DEVELOPMENT, 2004, 18 (12) :1413-1422

[4] EZH2 expression is associated with high proliferation rate and aggressive tumor subgroups in cutaneous melanoma and cancers of the endometrium, prostate, and breast [J].

Bachmann, IM ;

Halvorsen, OJ ;

Collett, K ;

Stefansson, IM ;

Straume, O ;

Haukaas, SA ;

Salvesen, HB ;

Otte, AP ;

Akslen, LA .

JOURNAL OF CLINICAL ONCOLOGY, 2006, 24 (02) :268-273

[5] Loss of BMI-1 expression is associated with clinical progress of malignant melanoma [J].

Bachmann, Ingeborg M. ;

Puntervoll, Hanne E. ;

Otte, Arie P. ;

Akslen, Lars A. .

MODERN PATHOLOGY, 2008, 21 (05) :583-590

[6] Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain [J].

Bannister, AJ ;

Zegerman, P ;

Partridge, JF ;

Miska, EA ;

Thomas, JO ;

Allshire, RC ;

Kouzarides, T .

NATURE, 2001, 410 (6824) :120-124

[7] Histone demethylase JMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RAS [J].

Barradas, Marta ;

Anderton, Emma ;

Acosta, Juan Carlos ;

Li, SiDe ;

Banito, Ana ;

Rodriguez-Niedenfuehr, Marc ;

Maertens, Goedele ;

Banck, Michaela ;

Zhou, Ming-Ming ;

Walsh, Martin J. ;

Peters, Gordon ;

Gil, Jesus .

GENES & DEVELOPMENT, 2009, 23 (10) :1177-1182

[8] Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints [J].

Bartkova, Jirina ;

Rezaei, Nousin ;

Liontos, Michalis ;

Karakaidos, Panagiotis ;

Kletsas, Dimitris ;

Issaeva, Natalia ;

Vassiliou, Leandros-Vassilios F. ;

Kolettas, Evangelos ;

Niforou, Katerina ;

Zoumpourlis, Vassilis C. ;

Takaoka, Munenori ;

Nakagawa, Hiroshi ;

Tort, Frederic ;

Fugger, Kasper ;

Johansson, Fredrik ;

Sehested, Maxwell ;

Andersen, Claus L. ;

Dyrskjot, Lars ;

Orntoft, Torben ;

Lukas, Jiri ;

Kittas, Christos ;

Helleday, Thomas ;

Halazonetis, Thanos D. ;

Bartek, Jiri ;

Gorgoulis, Vassilis G. .

NATURE, 2006, 444 (7119) :633-637

[9]

Beà S, 2001, CANCER RES, V61, P2409

[10] An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors [J].

Ben-Porath, Ittai ;

Thomson, Matthew W. ;

Carey, Vincent J. ;

Ge, Ruping ;

Bell, George W. ;

Regev, Aviv ;

Weinberg, Robert A. .

NATURE GENETICS, 2008, 40 (05) :499-507

← 1 2 3 4 5 6 7 8 9 10 →