Current role of biomarkers in carotid disease: a systematic review

被引：21

作者：

Avgerinos, Efthimios D. ^{[1
]}

Kadoglou, Nikolaos P. E. ^{[1
]}

Moulakakis, Konstantinos G. ^{[1
]}

Giannakopoulos, Triantafillos G. ^{[1
]}

Liapis, Christos D. ^{[1
]}

机构：

[1] Attikon Univ Hosp, Dept Vasc Surg, Sch Med, Athens, Greece

来源：

INTERNATIONAL JOURNAL OF STROKE | 2011年 / 6卷 / 04期

关键词：

carotid endarterectomy; carotid plaque; carotid stenosis; carotid stenting; ischemic stroke; risk factors; C-REACTIVE PROTEIN; CORONARY-HEART-DISEASE; CHLAMYDIA-PNEUMONIAE SEROPOSITIVITY; CONVENTIONAL RISK-FACTORS; LIPID-LOWERING THERAPY; ISCHEMIC-STROKE; MATRIX METALLOPROTEINASES; ARTERY STENOSIS; VASCULAR CALCIFICATION; CARDIOVASCULAR EVENTS;

D O I：

10.1111/j.1747-4949.2011.00623.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background and purpose Accumulating evidence suggests that carotid plaque vulnerability can be used as a determinant of ischemic stroke risk stratification and carotid intervention. Novelmarkers of high-risk carotid plaque in patients are needed. Summary of review Advances in cellular and molecular pathophysiology, the demand for accurately predicting carotid risk, and choosing the optimal prevention strategy are stimulating great interest in the development of novel surrogate markers. Biomarkers in cardiovascular disease are expected to predict the natural history, clinical outcomes, and the efficacy of disease-modifying interventions. We aimed to review the literature regarding clinical data on novel serum biomarkers related to ischemic cerebrovascular events associated with carotid artery disease. We provide background information on the biomarkers related to all aspects of carotid disease: natural history, carotid intervention strategies for symptomatic and asymptomatic patients, perioperative risk prediction, and their therapeutic implications. Conclusion At present, heterogeneous data support evidence that biological markers can help existing practices to more accurately assess patients at risk for stroke. Randomized-controlled trials for carotid artery disease and carotid intervention, incorporating biomarkers, are needed.

引用

页码：337 / 345

页数：9

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