Behavioral Problems in Fragile X Syndrome: A Review of Clinical Management

被引：9

作者：

Davidson, Michael ^{[1
]}

Sebastian, Sneha A. ^{[2
]}

Benitez, Yoanna ^{[1
]}

Desai, Shreeya ^{[2
]}

Quinonez, Jonathan ^{[3
]}

Ruxmohan, Samir ^{[4
]}

Stein, Joel D. ^{[5
,6
]}

Cueva, Wilson ^{[1
]}

机构：

[1] Larkin Community Hosp, Pediat, South Miami, FL USA

[2] Larkin Community Hosp, Res, South Miami, FL 33143 USA

[3] Larkin Community Hosp, Neurol Osteopath Neuromuscular Med, South Miami, FL USA

[4] Larkin Community Hosp, Neurol, South Miami, FL USA

[5] Lake Erie Coll Osteopath Med LECOM Bradenton, Osteopath Neuromuscular Med, Family Med, Sports Med,Pain Med, Bradenton, FL USA

[6] Larkin Community Hosp, Pain Management, Sports Med, Osteopath Neuromuscular Med, South Miami, FL USA

来源：

CUREUS JOURNAL OF MEDICAL SCIENCE | 2022年 / 14卷 / 02期

关键词：

psychopharmacology; fmr1; clinical management; behavioral problems; behavioral treatment; fragile x syndrome; DOUBLE-BLIND; CHILDREN; ACAMPROSATE; RISPERIDONE; AUTISM; MINOCYCLINE; IRRITABILITY; LOVASTATIN; RILUZOLE; DISORDER;

D O I：

10.7759/cureus.21840

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Fragile X syndrome (FXS) is noted to be the leading cause of inherited intellectual disabilities and is caused by expansive cytosine-guanine-guanine (CGG) trinucleotide repeats in the fragile X mental retardation 1 gene (FMR1). FXS can display a wide range of behavioral problems in addition to intellectual and developmental issues. Management of these problems includes both pharmacological and non-pharmacological options and research on these different management styles has been extensive in recent years. This narrative review aimed to collate recent evidence on the various management options of behavioral problems in FXS, including the pharmacological and non-pharmacological treatments, and also to provide a review of the newer avenues in the FXS treatment.

引用

页数：8

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