Therapeutic control and resistance of the EGFR-driven signaling network in glioblastoma

被引：32

作者：

Azuaje, Francisco ^{[1
]}

Tiemann, Katja ^{[1
]}

Niclou, Simone P. ^{[1
]}

机构：

[1] LIH, Dept Oncol, NorLux Neurooncol Lab, Luxembourg, Luxembourg

来源：

CELL COMMUNICATION AND SIGNALING | 2015年 / 13卷

关键词：

Epidermal growth factor receptor (EGFR); Targeted therapies; Resistance to treatment; Glioblastoma; Systems biology; GROWTH-FACTOR-RECEPTOR; PHASE-II TRIAL; KINASE INHIBITORS; TARGETED THERAPIES; LUNG-CANCER; TYROSINE KINASES; TUMOR-SUPPRESSOR; MUTANT EGFRVIII; GLIOMA; ACTIVATION;

D O I：

10.1186/s12964-015-0098-6

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The alteration of the epidermal growth factor receptor (EGFR)-driven signaling network is a characteristic feature of glioblastomas (GBM), and its inhibition represents a treatment strategy. However, EGFR-targeted interventions have been largely ineffective. Complex perturbations in this system are likely to be central to tumor cells with high adaptive capacity and resistance to therapies. We review key concepts and mechanisms relevant to EGFR-targeted treatment resistance at a systems level. Our understanding of treatment resistance as a systems-level phenomenon is necessary to develop effective therapeutic options for GBM patients. This is allowing us to go beyond the notion of therapeutic targets as single molecular components, into strategies that can weaken cancer signaling robustness and boost inherent network-level vulnerabilities.

引用

页数：13

共 95 条

[1] Function of the Blood-Brain Barrier and Restriction of Drug Delivery to Invasive Glioma Cells: Findings in an Orthotopic Rat Xenograft Model of Glioma [J].

Agarwal, Sagar ;

Manchanda, Pooja ;

Vogelbaum, Michael A. ;

Ohlfest, John R. ;

Elmquist, William F. .

DRUG METABOLISM AND DISPOSITION, 2013, 41 (01) :33-39

[2] A module of negative feedback regulators defines growth factor signaling [J].

Amit, Ido ;

Citri, Ami ;

Shay, Tal ;

Lu, Yiling ;

Katz, Menachem ;

Zhang, Fan ;

Tarcic, Gabi ;

Siwak, Doris ;

Lahad, John ;

Jacob-Hirsch, Jasmine ;

Amariglio, Ninette ;

Vaisman, Nora ;

Segal, Eran ;

Rechavi, Gideon ;

Alon, Uri ;

Mills, Gordon B. ;

Domany, Eytan ;

Yarden, Yosef .

NATURE GENETICS, 2007, 39 (04) :503-512

[3]

[Anonymous], SCI SIGNALING

[4] Feedback regulation of EGFR signalling: decision making by early and delayed loops [J].

Avraham, Roi ;

Yarden, Yosef .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2011, 12 (02) :104-117

[5] Proof of Concept: Network and Systems Biology Approaches Aid in the Discovery of Potent Anticancer Drug Combinations [J].

Azmi, Asfar S. ;

Wang, Zhiwei ;

Philip, Philip A. ;

Mohammad, Ramzi M. ;

Sarkar, Fazlul H. .

MOLECULAR CANCER THERAPEUTICS, 2010, 9 (12) :3137-3144

[6] Ligand-dependent responses of the ErbB signaling network: experimental and modeling analyses [J].

Birtwistle, Marc R. ;

Hatakeyama, Mariko ;

Yumoto, Noriko ;

Ogunnaike, Babatunde A. ;

Hoek, Jan B. ;

Kholodenko, Boris N. .

MOLECULAR SYSTEMS BIOLOGY, 2007, 3 (1)

[7] EGFR and EGFRvIII undergo stress- and EGFR kinase inhibitor-induced mitochondrial translocalization: A potential mechanism of EGFR-driven antagonism of apoptosis [J].

Cao, Xinyu ;

Zhu, Hu ;

Ali-Osman, Francis ;

Lo, Hui-Wen .

MOLECULAR CANCER, 2011, 10

[8] Comprehensive genomic characterization defines human glioblastoma genes and core pathways [J].

Chin, L. ;

Meyerson, M. ;

Aldape, K. ;

Bigner, D. ;

Mikkelsen, T. ;

VandenBerg, S. ;

Kahn, A. ;

Penny, R. ;

Ferguson, M. L. ;

Gerhard, D. S. ;

Getz, G. ;

Brennan, C. ;

Taylor, B. S. ;

Winckler, W. ;

Park, P. ;

Ladanyi, M. ;

Hoadley, K. A. ;

Verhaak, R. G. W. ;

Hayes, D. N. ;

Spellman, Paul T. ;

Absher, D. ;

Weir, B. A. ;

Ding, L. ;

Wheeler, D. ;

Lawrence, M. S. ;

Cibulskis, K. ;

Mardis, E. ;

Zhang, Jinghui ;

Wilson, R. K. ;

Donehower, L. ;

Wheeler, D. A. ;

Purdom, E. ;

Wallis, J. ;

Laird, P. W. ;

Herman, J. G. ;

Schuebel, K. E. ;

Weisenberger, D. J. ;

Baylin, S. B. ;

Schultz, N. ;

Yao, Jun ;

Wiedemeyer, R. ;

Weinstein, J. ;

Sander, C. ;

Gibbs, R. A. ;

Gray, J. ;

Kucherlapati, R. ;

Lander, E. S. ;

Myers, R. M. ;

Perou, C. M. ;

McLendon, Roger .

NATURE, 2008, 455 (7216) :1061-1068

[9] The quest to overcome resistance to EGFR-targeted therapies in cancer [J].

Chong, Curtis R. ;

Jaenne, Pasi A. .

NATURE MEDICINE, 2013, 19 (11) :1389-1400

[10] EGF-ERBB signalling: towards the systems level [J].

Citri, Ami ;

Yarden, Yosef .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2006, 7 (07) :505-516

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