BMP-Induced L-Maf Regulates Subsequent BMP-Independent Differentiation of Primary Lens Fibre Cells

被引:22
|
作者
Pandit, Tanushree [1 ]
Jidigam, Vijay K. [1 ]
Gunhaga, Lena [1 ]
机构
[1] Umea Univ, Umea Ctr Mol Med, S-90187 Umea, Sweden
关键词
lens; development; lens fibre cells; differentiation; BMP; L-Maf; delta-crystallin; chick; C-MAF; TRANSCRIPTION FACTOR; NEURAL INDUCTION; MESSENGER-RNA; PLACODE DEVELOPMENT; GENE-EXPRESSION; DISTINCT ROLES; CHICK-EMBRYOS; INSULIN GENE; BETA-CELLS;
D O I
10.1002/dvdy.22692
中图分类号
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号
100101 ;
摘要
Bone morphogenetic protein (BMP) signals are essential for lens development. However, the temporal requirement of BMP activity during early events of lens development has remained elusive. To investigate this question, we have used gain-and loss-of-function analyses in chick explant and intact embryo assays. Here, we show that BMP activity is both required and sufficient to induce L-Maf expression, whereas the onset of d-crystallin and initial elongation of primary lens fibre cells are BMP-independent. Moreover, before lens placode formation and L-Maf onset, but not after, prospective lens placodal cells can switch to an olfactory placodal fate in response to decreased BMP activity. In addition, L-Maf is sufficient to up-regulate d-crystallin independent of BMP signals. Taken together, these results show that before L-Maf induction BMP activity is required for lens specification, whereas after L-Maf up-regulation, the early differentiation of primary lens fibre cells occurs independent of BMP signals. Developmental Dynamics 240:1917-1928, 2011. (C) 2011 Wiley-Liss, Inc.
引用
收藏
页码:1917 / 1928
页数:12
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