B cells and progressive multifocal leukoencephalopathy: search for the missing link

被引：45

作者：

Durali, Deniz ^{[1
]}

de Herve, Marie-Ghislaine de Goer ^{[2
]}

Gasnault, Jacques ^{[2
]}

Taoufik, Yassine ^{[2
]}

机构：

[1] Istanbul Medipol Univ, Sch Med, Dept Med Microbiol, Immunol Res Lab, TR-34810 Istanbul, Turkey

[2] Univ Paris 11, Bicetre Hosp, Dept Immunol, IMVA INSERM U1184, Le Kremlin Bicetre, France

来源：

FRONTIERS IN IMMUNOLOGY | 2015年 / 6卷

关键词：

progressive multifocal leukoencephalopathy; JC virus; B cells; immune regulation; T cells; JC VIRUS-DNA; HEMATOPOIETIC PROGENITOR CELLS; INDUCED DEMYELINATING DISEASE; SYSTEMIC-LUPUS-ERYTHEMATOSUS; NONCODING CONTROL REGION; HUMORAL IMMUNE-RESPONSE; TONSILLAR STROMAL CELLS; HIV-NEGATIVE PATIENTS; ANTIGEN-SPECIFIC IGG; ADVERSE DRUG EVENTS;

D O I：

10.3389/fimmu.2015.00241

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Progressive multifocal leukoencephalopathy (PML) is a deadly demyelinating disease due to JC virus (JCV) replication in the brain. PML classically occurs in patients with severe immunodepression, and cases have recently been linked to therapeutic monoclonal antibodies such as natalizumab and also rituximab, which depletes B cells. B cells appear to play a complex role in the pathogenesis of PML. They may act as a viral reservoir and as a vector for viral dissemination in the central nervous system. Anti-JCV antibody responses appear to have a limited effect on JCV replication in the brain. However, accumulating evidence suggests that B cells may considerably influence T cell responses through their cytokine secretion. This immunomodulatory function of B cells may play an important role in the control of JCV infection and in the pathogenesis of PML, including rituximab-induced PML.

引用

页数：9

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