Microfluidic models for adoptive cell-mediated cancer immunotherapies

被引：53

作者：

Adriani, Giulia ^{[1
]}

Pavesi, Andrea ^{[1
]}

Tan, Anthony T. ^{[2
]}

Bertoletti, Antonio ^{[2
]}

Thiery, Jean Paul ^{[3
]}

Kamm, Roger D. ^{[1
,4
]}

机构：

[1] Singapore MIT Alliance Res & Technol, BioSyM IRG, 1 Create Way, Singapore 138602, Singapore

[2] DUKE NUS Grad Med Sch Singapore, Emerging Infect Dis Program, 8 Coll Rd, Singapore 169857, Singapore

[3] Natl Univ Singapore, Dept Biochem, Yong Loo Lin Sch Med MD7, 8 Med Dr, Singapore 117597, Singapore

[4] MIT, Dept Biol Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA

来源：

DRUG DISCOVERY TODAY | 2016年 / 21卷 / 09期

基金：

新加坡国家研究基金会;

关键词：

IN-VITRO MODEL; T-CELLS; 3D; CYTOKINE; MICROENVIRONMENT; METASTASIS; MECHANISMS; SPHEROIDS; CHEMOTHERAPY; MACROPHAGES;

D O I：

10.1016/j.drudis.2016.05.006

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Current adoptive T cell therapies have shown promising results in clinical trials but need further development as an effective cancer treatment. Here, we discuss how 3D microfluidic tumour models mimicking the tumour microenvironment could help in testing T cell immunotherapies by assessing engineered T cells and identifying combinatorial therapy to improve therapeutic efficacy. We propose that 3D microfluidic systems can be used to screen different patient-specific treatments, thereby reducing the burden of in vivo testing and facilitating the rapid translation of successful T cell cancer immunotherapies to the clinic.

引用

页码：1472 / 1478

页数：7

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