Biological Properties, Bioactive Constituents, and Pharmacokinetics of Some Capsicum spp. and Capsaicinoids

被引：141

作者：

Batiha, Gaber El-Saber ^{[1
]}

Alqahtani, Ali ^{[2
]}

Ojo, Oluwafemi Adeleke ^{[3
]}

Shaheen, Hazem M. ^{[1
]}

Wasef, Lamiaa ^{[1
]}

Elzeiny, Mahmoud ^{[1
]}

Ismail, Mahmoud ^{[1
]}

Shalaby, Mahmoud ^{[1
]}

Murata, Toshihiro ^{[4
]}

Zaragoza-Bastida, Adrian ^{[5
]}

Rivero-Perez, Nallely ^{[5
]}

Beshbishy, Amany Magdy ^{[6
]}

Kasozi, Keneth Iceland ^{[7
]}

Jeandet, Philippe ^{[8
]}

Hetta, Helal F. ^{[9
,10
]}

机构：

[1] Damanhour Univ, Fac Vet Med, Dept Pharmacol & Therapeut, Damanhour 22511, Albeheira, Egypt

[2] King Khalid Univ, Coll Pharm, Dept Pharmacol, Abha 62529, Saudi Arabia

[3] Landmark Univ, Dept Biochem, Omu Aran 251101, Nigeria

[4] Tohoku Med & Pharmaceut Univ, Dept Pharmacognosy, Aoba Ku, Sendai, Miyagi 9818558, Japan

[5] Univ Autonoma Estado Hidalgo, Area Acad Med Vet & Zootecnia, Inst Ciencias Agr, Rancho Univ Av Univ Km 1, Tulancingo 43600, Hidalgo, Mexico

[6] Obihiro Univ Agr & Vet Med, Natl Res Ctr Protozoan Dis, Nishi 2-13,Inada Cho, Obihiro, Hokkaido 0808555, Japan

[7] Univ Edinburgh, Coll Med & Vet Med, Infect Med, Deanery Biomed Sci, 1 George Sq, Edinburgh EH8 9JZ, Midlothian, Scotland

[8] Univ Reims, Res Unit Induced Resistance & Plant Bioprotect, EA 4707, SFR Condorcet FR CNRS 3417,Fac Sci, POB 1039, F-51687 Reims 2, France

[9] Assiut Univ, Fac Med, Dept Med Microbiol & Immunol, Assiut 71515, Egypt

[10] Univ Cincinnati, Dept Internal Med, Coll Med, Clifton Ave, Cincinnati, OH 45221 USA

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2020年 / 21卷 / 15期

关键词：

bioactive constituents; Capsicumspp; pharmacokinetics; ULTRASOUND-ASSISTED EXTRACTION; SUPERCRITICAL-FLUID EXTRACTION; PRESSURIZED LIQUID EXTRACTION; PEPPER SPRAY INJURY; RED CHILI-PEPPER; ANTIOXIDANT ACTIVITY; ANNUUM L; TOPICAL CAPSAICIN; SWEET-PEPPER; BACCATUM L;

D O I：

10.3390/ijms21155179

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pepper originated from theCapsicumgenus, which is recognized as one of the most predominant and globally distributed genera of the Solanaceae family. It is a diverse genus, consisting of more than 31 different species including five domesticated species,Capsicum baccatum,C. annuum,C. pubescen,C. frutescens, andC. chinense.Pepper is the most widely used spice in the world and is highly valued due to its pungency and unique flavor. Pepper is a good source of provitamin A; vitamins E and C; carotenoids; and phenolic compounds such as capsaicinoids, luteolin, and quercetin. All of these compounds are associated with their antioxidant as well as other biological activities. Interestingly,Capsicumfruits have been used as food additives in the treatment of toothache, parasitic infections, coughs, wound healing, sore throat, and rheumatism. Moreover, it possesses antimicrobial, antiseptic, anticancer, counterirritant, appetite stimulator, antioxidant, and immunomodulator activities. Capsaicin andCapsicumcreams are accessible in numerous ways and have been utilized in HIV-linked neuropathy and intractable pain.

引用

页码：1 / 35

页数：35

共 231 条

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