Highly efficient and convenient Strecker reaction of carbonyl compounds and amines with TMSCN catalyzed by MCM-41 anchored sulfonic acid as a recoverable catalyst

被引：103

作者：

Dekamin, Mohammad G. ^{[1
]}

Mokhtari, Zahra ^{[1
]}

机构：

[1] Iran Univ Sci & Technol, Dept Chem, Pharmaceut & Biol Act Cpds Res Lab, Tehran 1684613114, Iran

来源：

TETRAHEDRON | 2012年 / 68卷 / 03期

关键词：

MCM-41-SO3H nanocatalyst; Solid acid; Strecker reaction; alpha-Amino nitriles; Carbonyl compounds; TMSCN; ONE-POT SYNTHESIS; CYANOHYDRIN TRIMETHYLSILYL ETHERS; PHTHALIMIDE-N-OXYL; ALPHA-AMINONITRILES; ENANTIOSELECTIVE SYNTHESIS; POTASSIUM PHTHALIMIDE; MESOPOROUS AL-MCM-41; RECYCLABLE CATALYST; SELECTIVE SYNTHESIS; 3-COMPONENT;

D O I：

10.1016/j.tet.2011.10.087

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

MCM-41 anchored sulfonic acid (MCM-41-SO3H) was found to be a highly efficient and recoverable heterogeneous catalyst for the three-component Strecker reaction of aldehydes or ketones and diverse amines using trimethylsilyl cyanide (TMSCN) to afford the corresponding alpha-amino nitrites under mild conditions in high to quantitative yields. The simple experimental procedure along with easy recovery and reusability of the catalyst has led to development of a clean and environmentally friendly approach for the synthesis of a-amino nitrites. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：922 / 930

页数：9

共 98 条

[1] Dual-Activation Asymmetric Strecker Reaction of Aldimines and Ketimines Catalyzed by a Tethered Bis(8-quinolinolato) Aluminum Complex [J].