Control of cancer formation by intrinsic genetic noise and microenvironmental cues

被引：44
作者：
Brock, Amy [1 ]
Krause, Silva [2 ]
Ingber, Donald E. [3 ]
机构：
[1] Univ Texas Austin, Inst Cell & Mol Biol, Dept Biomed Engn, Austin, TX 78712 USA
[2] Momenta Pharmaceut, Cambridge, MA 02142 USA
[3] Harvard Univ, Wyss Inst Biol Inspired Engn, Boston, MA 02115 USA
来源：
NATURE REVIEWS CANCER | 2015年 / 15卷 / 08期
关键词：
EPITHELIAL-MESENCHYMAL TRANSITION; BREAST-CANCER; STEM-CELLS; IN-VIVO; EXTRACELLULAR-MATRIX; UROGENITAL SINUS; MELANOMA-CELLS; INTRATUMOR HETEROGENEITY; TUMOR MICROENVIRONMENT; VASCULAR NICHE;
D O I：
10.1038/nrc3959
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Differentiation therapies that induce malignant cells to stop growing and revert to normal tissue-specific differentiated cell types are successful in the treatment of a few specific haematological tumours. However, this approach has not been widely applied to solid tumours because their developmental origins are less well understood. Recent advances suggest that understanding tumour cell plasticity and how intrinsic factors (such as genetic noise and microenvironmental signals, including physical cues from the extracellular matrix) govern cell state switches will help in the development of clinically relevant differentiation therapies for solid cancers.
引用
收藏
页码：499 / 509
页数：11
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