The multifaceted biology of plasmacytoid dendritic cells

被引：860

作者：

Swiecki, Melissa ^{[1
,2
]}

Colonna, Marco ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA

[2] Janssen Res & Dev LLC, Spring House, PA 19477 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2015年 / 15卷 / 08期

关键词：

TOLL-LIKE RECEPTORS; I INTERFERON-PRODUCTION; IFN-ALPHA PRODUCTION; FACTOR SPI-B; SYSTEMIC-LUPUS-ERYTHEMATOSUS; DEPENDENT VIRAL RECOGNITION; PERSISTENT LCMV INFECTION; TRANSCRIPTION FACTOR E2-2; COLONY-STIMULATING FACTOR; IIFN-PRODUCING CELLS;

D O I：

10.1038/nri3865

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Plasmacytoid dendritic cells (pDCs) are a unique DC subset that specializes in the production of type I interferons (IFNs). pDCs promote antiviral immune responses and have been implicated in the pathogenesis of autoimmune diseases that are characterized by a type I IFN signature. However, pDCs can also induce tolerogenic immune responses. In this Review, we summarize recent progress in the field of pDC biology, focusing on the molecular mechanisms that regulate the development and functions of pDCs, the pathways involved in their sensing of pathogens and endogenous nucleic acids, their functions at mucosal sites, and their roles in infection, autoimmunity and cancer.

引用

页码：471 / 485

页数：15

共 252 条

[61]

Ewald SE, 2008, NATURE, V456, P658, DOI 10.1038/nature07405

[62] PLASMACYTOID MONOCYTES (SO-CALLED PLASMACYTOID T-CELLS) IN GRANULOMATOUS LYMPHADENITIS [J].

FACCHETTI, F ;

DEWOLFPEETERS, C ;

DEVOS, R ;

VANDENOORD, JJ ;

PULFORD, KAF ;

DESMET, VJ .

HUMAN PATHOLOGY, 1989, 20 (06) :588-593

[63] The plasmacytoid monocyte/interferon producing cells [J].

Facchetti, F ;

Vermi, W ;

Mason, D ;

Colonna, M .

VIRCHOWS ARCHIV, 2003, 443 (06) :703-717

[64] ICOS is associated with poor prognosis in breast cancer as it promotes the amplification of immunosuppressive CD4+ T cells by plasmacytoid dendritic cells [J].

Faget, Julien ;

Sisirak, Vanja ;

Blay, Jean-Yves ;

Caux, Christophe ;

Bendriss-Vermare, Nathalie ;

Menetrier-Caux, Christine .

ONCOIMMUNOLOGY, 2013, 2 (03)

[65] Murine plasmacytoid dendritic cells initiate the immunosuppressive pathway of tryptophan catabolism in response to CD200 receptor engagement [J].

Fallarino, F ;

Asselin-Paturel, C ;

Vacca, C ;

Bianchi, R ;

Gizzi, S ;

Fioretti, MC ;

Trinchieri, G ;

Grohmann, U ;

Puccetti, P .

JOURNAL OF IMMUNOLOGY, 2004, 173 (06) :3748-3754

[66] M-CSF: a novel plasmacytoid and conventional dendritic cell poietin [J].

Fancke, Ben ;

Suter, Mark ;

Hochrein, Hubertus ;

O'Keeffe, Meredith .

BLOOD, 2008, 111 (01) :150-159

[67] Human pDCs preferentially sense enveloped hepatitis A virions [J].

Feng, Zongdi ;

Li, You ;

McKnight, Kevin L. ;

Hensley, Lucinda ;

Lanford, Robert E. ;

Walker, Christopher M. ;

Lemon, Stanley M. .

JOURNAL OF CLINICAL INVESTIGATION, 2015, 125 (01) :169-176

[68] FcγRIIB Prevents Inflammatory Type I IFN Production from Plasmacytoid Dendritic Cells during a Viral Memory Response [J].

Flores, Marcella ;

Chew, Claude ;

Tyan, Kevin ;

Huang, Wu Qing ;

Salem, Aliasger ;

Clynes, Raphael .

JOURNAL OF IMMUNOLOGY, 2015, 194 (09) :4240-4250

[69] Independent of Plasmacytoid Dendritic Cell (pDC) infection, pDC Triggered by Virus-Infected Cells Mount Enhanced Type I IFN Responses of Different Composition as Opposed to pDC Stimulated with Free Virus [J].

Frenz, Theresa ;

Graalmann, Lukas ;

Detje, Claudia N. ;

Doering, Marius ;

Grabski, Elena ;

Scheu, Stefanie ;

Kalinke, Ulrich .

JOURNAL OF IMMUNOLOGY, 2014, 193 (05) :2496-2503

[70] Paradoxic inhibition of human natural interferon-producing cells by the activating receptor NKp44 [J].

Fuchs, A ;

Cella, M ;

Kondo, T ;

Colonna, M .

BLOOD, 2005, 106 (06) :2076-2082

← 2 3 4 5 6 7 8 9 10 11 →