The multifaceted biology of plasmacytoid dendritic cells

被引：859

作者：

Swiecki, Melissa ^{[1
,2
]}

Colonna, Marco ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA

[2] Janssen Res & Dev LLC, Spring House, PA 19477 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2015年 / 15卷 / 08期

关键词：

TOLL-LIKE RECEPTORS; I INTERFERON-PRODUCTION; IFN-ALPHA PRODUCTION; FACTOR SPI-B; SYSTEMIC-LUPUS-ERYTHEMATOSUS; DEPENDENT VIRAL RECOGNITION; PERSISTENT LCMV INFECTION; TRANSCRIPTION FACTOR E2-2; COLONY-STIMULATING FACTOR; IIFN-PRODUCING CELLS;

D O I：

10.1038/nri3865

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Plasmacytoid dendritic cells (pDCs) are a unique DC subset that specializes in the production of type I interferons (IFNs). pDCs promote antiviral immune responses and have been implicated in the pathogenesis of autoimmune diseases that are characterized by a type I IFN signature. However, pDCs can also induce tolerogenic immune responses. In this Review, we summarize recent progress in the field of pDC biology, focusing on the molecular mechanisms that regulate the development and functions of pDCs, the pathways involved in their sensing of pathogens and endogenous nucleic acids, their functions at mucosal sites, and their roles in infection, autoimmunity and cancer.

引用

页码：471 / 485

页数：15

共 252 条

[1] The miR-126-VEGFR2 axis controls the innate response to pathogen-associated nucleic acids [J].

Agudo, Judith ;

Ruzo, Albert ;

Tung, Navpreet ;

Salmon, Helene ;

Leboeuf, Marylene ;

Hashimoto, Daigo ;

Becker, Christian ;

Garrett-Sinha, Lee-Ann ;

Baccarini, Alessia ;

Merad, Miriam ;

Brown, Brian D. .

NATURE IMMUNOLOGY, 2014, 15 (01) :54-62

[2] Ikaros is required for plasmacytoid dendritic cell differentiation [J].

Allman, David ;

Dalod, Marc ;

Asselin-Paturel, Carine ;

Delale, Thomas ;

Robbins, Scott H. ;

Trinchieri, Giorgio ;

Biron, Christine A. ;

Kastner, Philippe ;

Chan, Susan .

BLOOD, 2006, 108 (13) :4025-4034

[3] Mouse type IIFN-producing cells are immature APCs with plasmacytoid morphology [J].

Asselin-Paturel, C ;

Boonstra, A ;

Dalod, M ;

Durand, I ;

Yessaad, N ;

Dezutter-Dambuyant, C ;

Vicari, A ;

O'Garra, A ;

Biron, C ;

Brière, F ;

Trinchieri, G .

NATURE IMMUNOLOGY, 2001, 2 (12) :1144-1150

[4] Essential requirement for IRF8 and SLC15A4 implicates plasmacytoid dendritic cells in the pathogenesis of lupus [J].

Baccala, Roberto ;

Gonzalez-Quintial, Rosana ;

Blasius, Amanda L. ;

Rimann, Ivo ;

Ozato, Keiko ;

Kono, Dwight H. ;

Beutler, Bruce ;

Theofilopoulos, Argyrios N. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (08) :2940-2945

[5] Anti-IFN-α/β Receptor Antibody Treatment Ameliorates Disease in Lupus-Predisposed Mice [J].

Baccala, Roberto ;

Gonzalez-Quintial, Rosana ;

Schreiber, Robert D. ;

Lawson, Brian R. ;

Kono, Dwight H. ;

Theofilopoulos, Argyrios N. .

JOURNAL OF IMMUNOLOGY, 2012, 189 (12) :5976-5984

[6] The transcriptional regulator NAB2 reveals a two-step induction of TRAIL in activated plasmacytoid DCs [J].

Balzarolo, Melania ;

Karrich, Julien J. ;

Engels, Sander ;

Blom, Bianca ;

Medema, Jan Paul ;

Wolkers, Monika C. .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2012, 42 (11) :3019-3027

[7] Regulation of TLR7/9 signaling in plasmacytoid dendritic cells [J].

Bao, Musheng ;

Liu, Yong-Jun .

PROTEIN & CELL, 2013, 4 (01) :40-52

[8] CD2AP/SHIP1 Complex Positively Regulates Plasmacytoid Dendritic Cell Receptor Signaling by Inhibiting the E3 Ubiquitin Ligase Cbl [J].

Bao, Musheng ;

Hanabuchi, Shino ;

Facchinetti, Valeria ;

Du, Qiumei ;

Bover, Laura ;

Plumas, Joel ;

Chaperot, Laurence ;

Cao, Wei ;

Qin, Jun ;

Sun, Shao-Cong ;

Liu, Yong-Jun .

JOURNAL OF IMMUNOLOGY, 2012, 189 (02) :786-792

[9] CX3CR1+ CD8α+ dendritic cells are a steady-state population related to plasmacytoid dendritic cells [J].

Bar-On, Liat ;

Birnberg, Tal ;

Lewis, Kanako L. ;

Edelson, Brian T. ;

Bruder, Dunja ;

Hildner, Kai ;

Buer, Jan ;

Murphy, Kenneth M. ;

Reizis, Boris ;

Jung, Steffen .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (33) :14745-14750

[10] Nucleic acids of mammalian origin can act as endogenous ligands for toll-like receptors and may promote systemic lupus erythematosus [J].

Barrat, FJ ;

Meeker, T ;

Gregorio, J ;

Chan, JH ;

Uematsu, S ;

Akira, S ;

Chang, B ;

Duramad, O ;

Coffman, RL .

JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 202 (08) :1131-1139

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