Vitamin D supplementation for osteoporosis in older adults: can we make it help better?

被引:1
作者
Dong, C. -H. [1 ,2 ]
Gao, Q. -M. [1 ]
Wang, Z. -M. [2 ]
Wang, A. -M. [2 ]
Zhen, P. [1 ]
机构
[1] Lanzhou Mil Command, Gen Hosp, PLA, Ctr Orthopaed Surg, Lanzhou, Gansu, Peoples R China
[2] Third Mil Med Univ, Daping Hosp, Inst Surg Res, Dept Orthoped, Chongqing, Peoples R China
关键词
Elderly; Osteoporosis; Vitamin D; Supplementation; Guidelines; Analysis; Biochemistry; Metabolism; Clinical efficacy; BONE-MINERAL DENSITY; PLACEBO-CONTROLLED TRIAL; SERUM 25-HYDROXYVITAMIN D; NURSING-HOME RESIDENTS; LONG-TERM-CARE; DOUBLE-BLIND; D DEFICIENCY; ORAL VITAMIN-D-3; FRACTURE RISK; ELDERLY-WOMEN;
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
With the increase of the average age of our population, the incidence of diseases specific for older adults has been increasing. One of such diseases is osteoporosis. The true incidence of osteoporosis is unknown. But the estimates indicate that this disease affects wide proportions of the population, ranging in millions or even ten millions in large countries like the United States. As this poses a significant burden on the health care system, interventions that could prevent or treat this condition are in the focus of clinical research. Vitamin D, the determinant of bone health, has been tested in clinical studies as the agent to treat osteoporosis. Despite the progress, there is still some controversy about the targeted blood levels of vitamin D, most efficient way to supplement this vitamin, and clinical efficacy of this supplementation in the elderly. In the present review, we will highlight the metabolism of vitamin D and the aforementioned unresolved issues, as well as review the recent interventional studies on vitamin D supplementation.
引用
收藏
页码:4612 / 4621
页数:10
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