Metal-Free Conjugate Addition of Alkenylboronic Acids to Enedicarbonyl Compounds towards the Synthesis of Pyridazine Derivatives

被引：5

作者：

Roscales, Silvia ^{[1
]}

Sancho, Ainhoa ^{[1
]}

Csaky, Aurelio G. ^{[1
]}

机构：

[1] Univ Complutense Madrid, Inst Pluridisciplinar, E-28040 Madrid, Spain

来源：

SYNTHESIS-STUTTGART | 2015年 / 47卷 / 15期

关键词：

boron; cyclization; isomerization; Michael addition; nucleophilic addition; BOND-FORMING REACTIONS; BORONIC ACIDS; CYCLOADDITION; 1,4-ADDITION; ALKENES; KETONES;

D O I：

10.1055/s-0034-1380525

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The regioselective conjugate addition of alkenylboronic acids to electronically-differentiated 1,4-enedicarbonyl compounds under metal-free conditions, using tartaric acid as promoter of the reaction is reported. The resulting compounds have been used as starting materials in the synthesis of 4-alkenyl-4,5-dihydropyridazin-3(2H)-ones or 4-alkylpyridazin-3(2H)-ones by reaction with hydrazine hydrate and acetic acid.

引用

页码：2233 / 2241

页数：9

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