Nitric Oxide Regulation of Bacterial Biofilms

被引:157
作者
Arora, Dhruv P. [1 ]
Hossain, Sajjad [3 ]
Xu, Yueming [1 ]
Boon, Elizabeth M. [1 ,2 ,3 ]
机构
[1] SUNY Stony Brook, Dept Chem, Stony Brook, NY 11794 USA
[2] SUNY Stony Brook, Inst Chem Biol & Drug Discovery, Stony Brook, NY 11794 USA
[3] SUNY Stony Brook, Grad Program Mol & Cellular Biol, Stony Brook, NY 11794 USA
关键词
SOLUBLE GUANYLATE-CYCLASE; CYCLIC-DI-GMP; 2-COMPONENT SIGNAL-TRANSDUCTION; QUORUM SENSING CIRCUIT; HEME-PROTEIN SENSORS; H-NOX REGULATION; PSEUDOMONAS-AERUGINOSA; TRANSCRIPTIONAL REGULATOR; RELEVANT MICROORGANISMS; NEISSERIA-GONORRHOEAE;
D O I
10.1021/bi501476n
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Biofilms are surface-associated, multicellular communities of bacteria. Once established, they are extremely difficult to eradicate by antimicrobial treatment. It has been demonstrated in many species that biofilm formation may be regulated by the diatomic signaling molecule nitric oxide (NO). Although this is still a relatively new area of research, we review here the literature reporting an effect of NO on bacterial biofilm formation, emphasizing dose-dependent responses to NO concentrations when possible. Where it has been investigated, the underlying NO sensors or signaling pathways are also discussed. Most of the examples of NO-mediated biofilm regulation have been documented with exogenously applied NO, but we also survey possible natural sources of NO in biofilm regulation, including endogenously generated NO. Finally, because of the apparent broad-spectrum, antibiofilm effects of NO, NO-releasing materials and prodrugs have also been explored in this minireview.
引用
收藏
页码:3717 / 3728
页数:12
相关论文
共 138 条
[1]   Nitric oxide synthases: structure, function and inhibition [J].
Alderton, WK ;
Cooper, CE ;
Knowles, RG .
BIOCHEMICAL JOURNAL, 2001, 357 (03) :593-615
[2]   Quorum sensing in bacterial virulence [J].
Antunes, L. Caetano M. ;
Ferreira, Rosana B. R. ;
Buckner, Michelle M. C. ;
Finlay, B. Brett .
MICROBIOLOGY-SGM, 2010, 156 :2271-2282
[3]   Nitric oxide regulated two-component signaling in Pseudoalteromonas atlantica [J].
Arora, Dhruv P. ;
Boon, Elizabeth M. .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2012, 421 (03) :521-526
[4]   Scavenging of reactive nitrogen species by mycobacterial truncated hemoglobins [J].
Ascenzi, Paolo ;
Visca, Paolo .
GLOBINS AND OTHER NITRIC OXIDE-REACTIVE PROTEINS, PT A, 2008, 436 :317-337
[5]  
Barraud N., 2009, J BACTERIOL
[6]   Involvement of nitric oxide in biofilm dispersal of Pseudomonas aeruginosa [J].
Barraud, Nicolas ;
Hassett, Daniel J. ;
Hwang, Sung-Hei ;
Rice, Scott A. ;
Kjelleberg, Staffan ;
Webb, Jeremy S. .
JOURNAL OF BACTERIOLOGY, 2006, 188 (21) :7344-7353
[7]  
Barraud N, 2015, CURR PHARM DESIGN, V21, P31, DOI 10.2174/1381612820666140905112822
[8]   Cephalosporin-3′-diazeniumdiolates: Targeted NO-Donor Prodrugs for Dispersing Bacterial Biofilms [J].
Barraud, Nicolas ;
Kardak, Bharat G. ;
Yepuri, Nageshwar R. ;
Howlin, Robert P. ;
Webb, Jeremy S. ;
Faust, Saul N. ;
Kjelleberg, Staffan ;
Rice, Scott A. ;
Kelso, Michael J. .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2012, 51 (36) :9057-9060
[9]   Nitric oxide-mediated dispersal in single- and multi-species biofilms of clinically and industrially relevant microorganisms [J].
Barraud, Nicolas ;
Storey, Michael V. ;
Moore, Zoe P. ;
Webb, Jeremy S. ;
Rice, Scott A. ;
Kjelleberg, Staffan .
MICROBIAL BIOTECHNOLOGY, 2009, 2 (03) :370-378
[10]   Vascular System: Role of Nitric Oxide in Cardiovascular Diseases [J].
Bian, Ka ;
Doursout, Marie-Francoise ;
Murad, Ferid .
JOURNAL OF CLINICAL HYPERTENSION, 2008, 10 (04) :304-310