pH-Tunable Calcium Phosphate Covered Mesoporous Silica Nanocontainers for Intracellular Controlled Release of Guest Drugs

被引：215
作者：
Rim, Hwa Pyeong [1 ]
Min, Kyung Hyun [1 ]
Lee, Hong Jae [2 ,3 ]
Jeong, Seo Young [1 ]
Lee, Sang Cheon [2 ,3 ]
机构：
[1] Kyung Hee Univ, Dept Life & Nanopharmaceut Sci, Seoul 130701, South Korea
[2] Kyung Hee Univ, Dept Maxillofacial Biomed Engn, Sch Dent, Seoul 130701, South Korea
[3] Kyung Hee Univ, Inst Oral Biol, Sch Dent, Seoul 130701, South Korea
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 38期
关键词：
drug delivery; host-guest systems; mesoporous materials; mineralization; nanoparticles; RESPONSIVE CONTROLLED-RELEASE; HYDROXYAPATITE; DELIVERY; SYSTEM; IMMOBILIZATION; MINERALIZATION; NANOPARTICLES; NANOVALVES; NANOSPHERE; UREASE;
D O I：
10.1002/anie.201101536
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Springing the trap: A pH-responsive mesoporous silica nanoparticle with a calcium phosphate (CaP) pore-blocking coating was developed by enzyme-mediated surface mineralization under mild conditions. Upon exposure to cellular lysosomal pH, guest anticancer drug was released from the pore by dissolution of the CaP pore blocker (see picture; HAp=hydroxyapatite). © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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收藏
页码：8853 / 8857
页数：5
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