Tertiary lymphoid structures in cancer - considerations for patient prognosis

被引：146

作者：

Munoz-Erazo, Luis ^{[1
]}

Rhodes, Janet L. ^{[1
]}

Marion, Valentine C. ^{[2
,3
]}

Kemp, Roslyn A. ^{[1
]}

机构：

[1] Univ Otago, Dept Microbiol & Immunol, Dunedin, New Zealand

[2] Ecole Normale Super Lyon, Lyon, France

[3] Univ Claude Bernard Lyon 1, Lyon, France

来源：

CELLULAR & MOLECULAR IMMUNOLOGY | 2020年 / 17卷 / 06期

关键词：

tertiary lymphoid structure; prognosis; cancer; tissue; TUMOR-INFILTRATING LYMPHOCYTE; T-CELL INFILTRATION; B-CELLS; SURVIVAL; IMMUNOTHERAPY; METASTASES; CHEMOKINES; MELANOMA; IMMUNITY;

D O I：

10.1038/s41423-020-0457-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Tertiary lymphoid structures (TLS) are ectopic lymphoid formations that form within nonlymphoid tissue. They share structural and functional characteristics with secondary lymphoid structures such as lymph nodes and can contain B-cell follicles and germinal centers surrounded by a T-cell region. TLS have been described in several types of cancers and are usually associated with positive patient outcomes. However, TLS differ vastly in cellular composition and location within tissue types. In this review, we discuss factors confounding the interpretation of the evidence for a prognostic role for TLS in cancer and frame these factors in the context of translation to regular clinical use.

引用

页码：570 / 575

页数：6

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