Whole-genome sequence of Schistosoma haematobium

被引：326

作者：

Young, Neil D. ^{[1
]}

Jex, Aaron R. ^{[1
]}

Li, Bo ^{[2
]}

Liu, Shiping ^{[2
]}

Yang, Linfeng ^{[2
]}

Xiong, Zijun ^{[2
]}

Li, Yingrui ^{[2
]}

Cantacessi, Cinzia ^{[1
]}

Hall, Ross S. ^{[1
]}

Xu, Xun ^{[2
]}

Chen, Fangyuan ^{[2
]}

Wu, Xuan ^{[2
]}

Zerlotini, Adhemar ^{[3
]}

Oliveira, Guilherme ^{[3
]}

Hofmann, Andreas ^{[1
,4
]}

Zhang, Guojie ^{[2
]}

Fang, Xiaodong ^{[2
]}

Kang, Yi ^{[2
]}

Campbell, Bronwyn E. ^{[1
]}

Loukas, Alex ^{[5
]}

Ranganathan, Shoba ^{[6
,7
]}

Rollinson, David ^{[8
]}

Rinaldi, Gabriel ^{[9
,10
]}

Brindley, Paul J. ^{[10
]}

Yang, Huanming ^{[2
]}

Wang, Jun ^{[2
]}

Wang, Jian ^{[2
]}

Gasser, Robin B. ^{[1
]}

机构：

[1] Univ Melbourne, Fac Vet Sci, Melbourne, Vic 3010, Australia

[2] BGI Shenzhen, Shenzhen, Peoples R China

[3] Inst Pesquisa Rene Rachou Fiocruz, Inst Nacl Ciencia & Tecnol Doencas Tropicais, Belo Horizonte, MG, Brazil

[4] Griffith Univ, Eskitis Inst Cell & Mol Therapies, Brisbane, Qld 4111, Australia

[5] James Cook Univ, Sch Publ Hlth Trop Med & Rehabil Sci, Cairns, Qld, Australia

[6] Macquarie Univ, Dept Chem & Biomol Sci, Sydney, NSW 2109, Australia

[7] Natl Univ Singapore, Dept Biochem, Singapore 117548, Singapore

[8] Nat Hist Museum, London SW7 5BD, England

[9] Univ Republica, Dept Genet, Montevideo, Uruguay

[10] George Washington Univ, Dept Microbiol Immunol & Trop Med, Washington, DC USA

来源：

NATURE GENETICS | 2012年 / 44卷 / 02期

基金：

澳大利亚研究理事会; 澳大利亚国家健康与医学研究理事会; 英国医学研究理事会;

关键词：

HUMAN BLOOD FLUKE; GENETIC MANIPULATION; MANSONI; JAPONICUM; PATHOGEN; IMMUNITY; TARGETS; HEALTH;

D O I：

10.1038/ng.1065

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Schistosomiasis is a neglected tropical disease caused by blood flukes (genus Schistosoma; schistosomes) and affecting 200 million people worldwide(1). No vaccines are available, and treatment relies on one drug, praziquantel(2). Schistosoma haematobium has come into the spotlight as a major cause of urogenital disease, as an agent linked to bladder cancer(1,3) and as a predisposing factor for HIV/AIDS(4,5). The parasite is transmitted to humans from freshwater snails'. Worms dwell in blood vessels and release eggs that become embedded in the bladder wall to elicit chronic immune-mediated disease(6) and induce squamous cell carcinoma(7). Here we sequenced the 385-Mb genome of S. haematobium using Illumina-based technology at 74-fold coverage and compared it to sequences from related parasites(8,9). We included genome annotation based on function, gene ontology, networking and pathway mapping. This genome now provides an unprecedented resource for many fundamental research areas and shows great promise for the design of new disease interventions.

引用

页码：221 / 225

页数：5

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