Microwave assisted synthesis of indole-annulated dihydropyrano[3,4-c] chromene derivatives via hetero-Diels-Alder reaction

被引：30

作者：

Jha, Mukund ^{[1
]}

Guy, Stephanie ^{[1
]}

Chou, Ting-Yi ^{[1
]}

机构：

[1] Nipissing Univ, Dept Biol & Chem, N Bay, ON P1B 8L7, Canada

来源：

TETRAHEDRON LETTERS | 2011年 / 52卷 / 33期

基金：

加拿大自然科学与工程研究理事会;

关键词：

Indole; Indolin-2-one; Dihydropyran; Chromene; Benzopyran; Hetero-Diels-Alder; Knoevenagel reaction; COMBINATORIAL LIBRARIES; PRIVILEGED STRUCTURES; TERMINAL ACETYLENES; EFFICIENT SYNTHESIS; NATURAL-PRODUCTS; AQUEOUS-MEDIA;

D O I：

10.1016/j.tetlet.2011.06.052

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient two-step synthesis of indole-annulated dihydropyrano[3,4-c]chromene derivatives is achieved via Knoevenagel condensation of O-propargylated salicylaldehyde derivatives with indolin-2-ones followed by a microwave-assisted intramolecular-hetero-Diels-Alder reaction of the resulting (Z)-3-(2-(prop-2-ynyloxy)benzylidene)indolin-2-ones in the presence of 20 mol % Cul in acetonitrile. (C) 2011 Elsevier Ltd. All rights reserved.

引用

收藏

页码：4337 / 4341

页数：5

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