The polymorphism of XRCC3 codon 241 and AFB1-related hepatocellular carcinoma in Guangxi population, China

被引：37

作者：

Long, Xi Dai ^{[1
]}

Ma, Yun ^{[2
]}

Qu, De Ying ^{[1
]}

Liu, Yun Guang ^{[3
]}

Huang, Zhao Quan ^{[1
]}

Huang, Yong Zhi ^{[1
]}

Lin, Zhong Hui ^{[4
]}

Wei, Ni Bo ^{[5
]}

Zhou, Shu Chun ^{[6
]}

机构：

[1] Youjiang Med Coll Natl, Dept Pathol, Baise, Guangxi Zhuang, South Korea

[2] Guangxi Med Univ, Dept Pathol, Nanning, Guangxi Zhuang, Peoples R China

[3] Youjiang Med Coll Natl, Affiliated Hosp, Dept Med, Baise, Guangxi Zhuang, South Korea

[4] Zhong Hosp Xiamen, Dept Med, Xiamen, Fujian Province, Peoples R China

[5] Youjiang Med Coll Natl, Dept Clin Med 2004, Baise, Guangxi Zhuang, Peoples R China

[6] Second Hosp Anhua, Dept Clin Med, Anhua, Hunan, Peoples R China

来源：

ANNALS OF EPIDEMIOLOGY | 2008年 / 18卷 / 07期

基金：

中国国家自然科学基金;

关键词：

HCC; XRCC3; polymorphism; AFB1;

D O I：

10.1016/j.annepidem.2008.03.003

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

PURPOSE: The relationship between aflatoxin B1 (AFB1) exposure and hepatocellular carcinoma (HCC) has been previously demonstrated and supported with strong epidemiological evidence. However, the role of genetic polymorphism of X-ray cross-complementing group 3 (XRCC3) codon 241 (namely: Thr241Met), which may be involved in the repair of DNA double-strand breaks caused by carcinogens such as AFB1, been less well elaborated. METHODS: We conducted a case-control study including 491 cases and 862 controls to evaluate the associations between this polymorphism and HCC risk for Guangxi population by means of polymerase chain reaction-restriction fragment length polymorphism analysis. RESULTS: We found that individuals with the XRCC3 genotypes with codon 241 Met (namely XRCC3-TM or XRCC3-MM) had an increased risk of HCC than those with the homozygote of XRCC3 codon 241 Thr alleles (namely XRCC3-TT, adjusted odds ratios 2.22 and 7.19; 95% confidence intervals 1.72-2.88 and 4.52-11-42, respectively). The risk of HCC, moreover, did appear to differ more significantly among individuals featuring high-level AFB1-DNA adducts, whose adjusted odds ratios (95% confidence intervals) were 11.59 (5.73-23-47) and 37.54 (16.32-86.32), respectively. CONCLUSIONS: These findings support the hypothesis that the XRCC3 Thr241Met polymorphism may be associated with the risk of AFB1-related HCC among the Guangxi population.

引用

页码：572 / 578

页数：7

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