BRCA1 Is Required for Postreplication Repair after UV-Induced DNA Damage

被引：90
作者：
Pathania, Shailja [1 ,4 ]
Jenna Nguyen [4 ]
Hill, Sarah J. [4 ]
Scully, Ralph [2 ,6 ]
Adelmant, Guillaume O. [3 ,4 ,5 ]
Marto, Jarrod A. [3 ,4 ,5 ]
Feunteun, Jean [7 ]
Livingston, David M. [1 ,4 ]
机构：
[1] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA
[3] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA
[4] Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02215 USA
[5] Dana Farber Canc Inst, Blais Prote Ctr, Boston, MA 02215 USA
[6] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA
[7] Inst Gustave Roussy, UMR8200, Lab Stabilite Genet & Oncogenese, F-94805 Villejuif, France
来源：
MOLECULAR CELL | 2011年 / 44卷 / 02期
基金：
美国国家卫生研究院;
关键词：
NUCLEOTIDE EXCISION-REPAIR; STALLED REPLICATION FORKS; POLYMERASE-ETA; HOMOLOGOUS RECOMBINATION; XERODERMA-PIGMENTOSUM; GENOMIC INSTABILITY; S-PHASE; CHECKPOINT; BREAST; CANCER;
D O I：
10.1016/j.molcel.2011.09.002
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
BRCA1 contributes to the response to UV irradiation. Utilizing its BRCT motifs, it is recruited during S/G2 to UV-damaged sites in a DNA replication-dependent but nucleotide excision repair (NER)-independent manner. More specifically, at UV-stalled replication forks, it promotes photoproduct excision, suppression of translesion synthesis, and the localization and activation of replication factor C complex (RFC) subunits. The last function, in turn, triggers post-UV checkpoint activation and postreplicative repair. These BRCA1 functions differ from those required for DSBR.
引用
收藏
页码：235 / 251
页数：17
相关论文
共 68 条
  • [1] The ERCC1/XPF endonuclease is required for completion of homologous recombination at DNA replication forks stalled by inter-strand cross-links
    Al-Minawi, Ali Z.
    Lee, Yin-Fai
    Hakansson, Daniel
    Johansson, Fredrik
    Lundin, Cecilia
    Saleh-Gohari, Nasrollah
    Schultz, Niklas
    Jenssen, Dag
    Bryant, Helen E.
    Meuth, Mark
    Hinz, John M.
    Helleday, Thomas
    [J]. NUCLEIC ACIDS RESEARCH, 2009, 37 (19) : 6400 - 6413
  • [2] Defective Repair of Oxidative DNA Damage in Triple-Negative Breast Cancer Confers Sensitivity to Inhibition of Poly(ADP-Ribose) Polymerase
    Alli, Elizabeth
    Sharma, Vandana B.
    Sunderesakumar, Preethi
    Ford, James M.
    [J]. CANCER RESEARCH, 2009, 69 (08) : 3589 - 3596
  • [3] The BRCA1 RING and BRCT domains cooperate in targeting BRCA1 to ionizing radiation-induced nuclear foci
    Au, WWY
    Henderson, BR
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (08) : 6993 - 7001
  • [4] DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
    Bartkova, J
    Horejsi, Z
    Koed, K
    Krämer, A
    Tort, F
    Zieger, K
    Guldberg, P
    Sehested, M
    Nesland, JM
    Lukas, C
    Orntoft, T
    Lukas, J
    Bartek, J
    [J]. NATURE, 2005, 434 (7035) : 864 - 870
  • [5] Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro
    Bermudez, VP
    Lindsey-Boltz, LA
    Cesare, AJ
    Maniwa, Y
    Griffith, JD
    Hurwitz, J
    Sancar, A
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (04) : 1633 - 1638
  • [6] Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase
    Bulavin, DV
    Higashimoto, Y
    Popoff, IJ
    Gaarde, WA
    Basrur, V
    Potapova, O
    Appella, E
    Fornace, AJ
    [J]. NATURE, 2001, 411 (6833) : 102 - 107
  • [7] Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint
    Byun, TS
    Pacek, M
    Yee, MC
    Walter, JC
    Cimprich, KA
    [J]. GENES & DEVELOPMENT, 2005, 19 (09) : 1040 - 1052
  • [8] Structural characterization of human RPA sequential binding to single-stranded DNA using ssDNA as a molecular ruler
    Cai, Lifeng
    Roginskaya, Marina
    Qu, Youxing
    Yang, Zhengguan
    Xu, Ying
    Zou, Yue
    [J]. BIOCHEMISTRY, 2007, 46 (28) : 8226 - 8233
  • [9] Shedding light on the DNA damage checkpoint
    Callegari, A. John
    Kelly, Thomas J.
    [J]. CELL CYCLE, 2007, 6 (06) : 660 - 666
  • [10] UV LIGHT-INDUCED DNA-SYNTHESIS ARREST IN HELA-CELLS IS ASSOCIATED WITH CHANGES IN PHOSPHORYLATION OF HUMAN SINGLE-STRANDED DNA-BINDING PROTEIN
    CARTY, MP
    ZERNIKKOBAK, M
    MCGRATH, S
    DIXON, K
    [J]. EMBO JOURNAL, 1994, 13 (09) : 2114 - 2123
1234567