The use of EEG parameters as predictors of drug effects on cognition

被引：16

作者：

Blokland, Arjan ^{[1
]}

Prickaerts, Jos ^{[2
]}

van Duinen, Marlies ^{[2
]}

Sambeth, Anke ^{[1
]}

机构：

[1] Maastricht Univ, Fac Psychol & Neurosci, European Sch Neurosci EURON, Dept Neuropsychol & Psychophannacol, NL-6200 MD Maastricht, Netherlands

[2] Maastricht Univ, Fac Hlth Med & Life Sci, European Sch Neurosci EURON, Dept Psychiat & Neuropsychol, NL-6200 MD Maastricht, Netherlands

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2015年 / 759卷

关键词：

Cognition; Translational; Drug research; Cholinergic; Event-related potentials; Coherence analysis; EVENT-RELATED POTENTIALS; CHOLINESTERASE-INHIBITORS; NETWORK CONNECTIVITY; OBJECT RECOGNITION; HIPPOCAMPAL; MODELS; MEMORY; RATS; OSCILLATIONS; MODULATION;

D O I：

10.1016/j.ejphar.2015.03.031

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

It has been shown to be difficult to predict whether cognition-enhancing effects of drugs in animal studies have the same effect in humans. Various issues in translating findings from animal to human studies can be identified. Here we discuss whether EEG could be considered as a possible tool to translate the effects of cognition enhancers across species. Three different aspects of EEG measures are evaluated: frequency bands, event-related potentials, and coherence analysis. On basis of the comparison of these measures between species, and effects of drugs that improve or impair memory performance (mainly cholinergic drugs), it appears that event-related potentials and coherence analyses could be considered as potential translational tools to study cognition-enhancing drug effects in rodents and animals. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：163 / 168

页数：6

共 59 条

[1] Cortical EEG oscillations and network connectivity as efficacy indices for assessing drugs with cognition enhancing potential [J].