Value of (1-3)-β-D-glucan, Candida mannan and Candida DNA detection in the diagnosis of candidaemia

被引：16
|
作者：
Mokaddas, E. [1 ]
Khan, Z. U. [1 ]
Ahmad, S. [1 ]
Nampoory, M. R. N. [2 ]
Burhamah, M. [3 ]
机构：
[1] Kuwait Univ, Dept Microbiol, Fac Med, Shuwaikh, Kuwait
[2] Hamed Al Essa Organ Transplant Ctr, Shuwaikh, Kuwait
[3] Al Sabah Hosp, NBK Canc Ward, Shuwaikh, Kuwait
来源：
CLINICAL MICROBIOLOGY AND INFECTION | 2011年 / 17卷 / 10期
关键词：
(1-3)-beta-D-glucan; Candida DNA; Candida mannan; candidaemia; diagnosis; INVASIVE FUNGAL-INFECTIONS; BETA-D-GLUCAN; ANTIMANNAN ANTIBODIES; ASSAY; PCR; IDENTIFICATION; DUBLINIENSIS; IMMUNOASSAY; ANTIGENS; LEUKEMIA;
D O I：
10.1111/j.1469-0691.2011.03608.x
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
This study determined the value of (1,3)-beta-D-glucan (BDG), Candida mannan (MN) and Candida species-specific DNA as surrogates for diagnosis of candidaemia. Thirty-nine patients yielding Candida species in blood cultures were investigated for presence of BDG, MN and Candida species-specific DNA in serum samples. The Candida spp. bloodstream isolates included C. albicans (n = 16), C. tropicalis (n = 10), C. parapsilosis (n = 7), C. glabrata (n = 3) and C. dubliniensis (n = 3). Positivity of the three markers was as follows: Candida DNA for corresponding Candida species, 100%; BDG, 87%; MN, 59%. Despite varying sensitivities of these biomarkers, they provided a useful adjunct to the diagnosis of candidaemia.
引用
收藏
页码：1549 / 1553
页数：6
相关论文
共 50 条
  • [21] Caution when using 1,3, β-D-glucan in the CSF as a biomarker of Candida albicans meningitis
    Barbolini, Laura
    Riat, Arnaud
    Van Delden, Christian
    Schrenzel, Jacques
    INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2022, 122 : 531 - 533
  • [22] Diagnostic accuracy of serum (1-3)-β-D-glucan for Pneumocystis jirovecii pneumonia: a systematic review and meta-analysis
    Del Corpo, Olivier
    Butler-Laporte, Guillaume
    Sheppard, Donald C.
    Cheng, Matthew P.
    McDonald, Emily G.
    Lee, Todd C.
    CLINICAL MICROBIOLOGY AND INFECTION, 2020, 26 (09) : 1137 - 1143
  • [23] Serum (1-3)-β-D-Glucan as a Tool for Diagnosis of Pneumocystis jirovecii Pneumonia in Patients with Human Immunodeficiency Virus Infection or Hematological Malignancy
    Desmet, Stefanie
    Van Wijngaerden, Eric
    Maertens, Johan
    Verhaegen, Jan
    Verbeken, Eric
    De Munter, Paul
    Meersseman, Wouter
    Van Meensel, Britt
    Van Eldere, Johan
    Lagrou, Katrien
    JOURNAL OF CLINICAL MICROBIOLOGY, 2009, 47 (12) : 3871 - 3874
  • [24] Diagnostic accuracy of fungal PCR and β-D-glucan for detection of candidaemia: a preliminary evaluation
    McKeating, Cara
    White, P. Lewis
    Posso, Raquel
    Palmer, Michael
    Johnson, Elizabeth
    McMullan, Ronan
    JOURNAL OF CLINICAL PATHOLOGY, 2018, 71 (05) : 420 - 424
  • [25] Rapid diagnosis of candidaemia by real-time PCR detection of Candida DNA in blood samples
    Wellinghausen, Nele
    Siegel, Dunja
    Winter, Juliane
    Gebert, Susanne
    JOURNAL OF MEDICAL MICROBIOLOGY, 2009, 58 (08) : 1106 - 1111
  • [26] Detection of fungal DNA in peritoneal fluids by a PCR DNA low-density microarray system and quantitation of serum (1-3)-β-D-glucan in the diagnosis of peritoneal candidiasis
    Corrales, Isabel
    Gimenez, Estela
    Aguilar, Gerardo
    Delgado, Carlos
    Puig, Jaime
    Izquierdo, Ana
    Belda, Javier
    Navarro, David
    MEDICAL MYCOLOGY, 2015, 53 (02) : 199 - 204
  • [27] Measuring (1,3)-β-D-glucan in tracheal aspirate, bronchoalveolar lavage fluid, and serum for detection of suspected Candida pneumonia in immunocompromised and critically ill patients: a prospective observational study
    Su, Kang-Cheng
    Chou, Kun-Ta
    Hsiao, Yi-Han
    Tseng, Ching-Min
    Su, Vincent Yi-Fong
    Lee, Yu-Chin
    Perng, Diahn-Warng
    Kou, Yu Ru
    BMC INFECTIOUS DISEASES, 2017, 17
  • [28] Invasive pulmonary aspergillosis due to Aspergillus terreus value of DNA, galactomannan and (1→3)-β-D-glucan detection in serum samples as an adjunct to diagnosis
    Mokaddas, E.
    Burhamah, M. H. A.
    Ahmad, S.
    Khan, Z. U.
    JOURNAL OF MEDICAL MICROBIOLOGY, 2010, 59 (12) : 1519 - 1523
  • [29] An evaluation of the performance of the Dynamiker® Fungus (1-3)-β-D-Glucan Assay to assist in the diagnosis of Pneumocystis pneumonia
    White, P. Lewis
    Posso, Raquel B.
    Gorton, Rebecca L.
    Price, Jessica S.
    Wey, E.
    Barnes, Rosemary A.
    MEDICAL MYCOLOGY, 2018, 56 (06) : 778 - 781
  • [30] Combined use of serum (1,3)-β-D-glucan and procalcitonin for the early differential diagnosis between candidaemia and bacteraemia in intensive care units
    Giacobbe, Daniele Roberto
    Mikulska, Malgorzata
    Tumbarello, Mario
    Furfaro, Elisa
    Spadaro, Marzia
    Losito, Angela Raffaella
    Mesini, Alessio
    De Pascale, Gennaro
    Marchese, Anna
    Bruzzone, Marco
    Pelosi, Paolo
    Mussap, Michele
    Molin, Alexandre
    Antonelli, Massimo
    Posteraro, Brunella
    Sanguinetti, Maurizio
    Viscoli, Claudio
    Del Bono, Valerio
    CRITICAL CARE, 2017, 21
12345