Value of (1-3)-β-D-glucan, Candida mannan and Candida DNA detection in the diagnosis of candidaemia

被引：16
|
作者：
Mokaddas, E. [1 ]
Khan, Z. U. [1 ]
Ahmad, S. [1 ]
Nampoory, M. R. N. [2 ]
Burhamah, M. [3 ]
机构：
[1] Kuwait Univ, Dept Microbiol, Fac Med, Shuwaikh, Kuwait
[2] Hamed Al Essa Organ Transplant Ctr, Shuwaikh, Kuwait
[3] Al Sabah Hosp, NBK Canc Ward, Shuwaikh, Kuwait
来源：
CLINICAL MICROBIOLOGY AND INFECTION | 2011年 / 17卷 / 10期
关键词：
(1-3)-beta-D-glucan; Candida DNA; Candida mannan; candidaemia; diagnosis; INVASIVE FUNGAL-INFECTIONS; BETA-D-GLUCAN; ANTIMANNAN ANTIBODIES; ASSAY; PCR; IDENTIFICATION; DUBLINIENSIS; IMMUNOASSAY; ANTIGENS; LEUKEMIA;
D O I：
10.1111/j.1469-0691.2011.03608.x
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
This study determined the value of (1,3)-beta-D-glucan (BDG), Candida mannan (MN) and Candida species-specific DNA as surrogates for diagnosis of candidaemia. Thirty-nine patients yielding Candida species in blood cultures were investigated for presence of BDG, MN and Candida species-specific DNA in serum samples. The Candida spp. bloodstream isolates included C. albicans (n = 16), C. tropicalis (n = 10), C. parapsilosis (n = 7), C. glabrata (n = 3) and C. dubliniensis (n = 3). Positivity of the three markers was as follows: Candida DNA for corresponding Candida species, 100%; BDG, 87%; MN, 59%. Despite varying sensitivities of these biomarkers, they provided a useful adjunct to the diagnosis of candidaemia.
引用
收藏
页码：1549 / 1553
页数：6
相关论文
共 50 条
  • [1] Levels of (1→3)-β-D-glucan, Candida mannan and Candida DNA in serum samples of pediatric cancer patients colonized with Candida species
    Mokaddas, Eiman
    Burhamah, Mona H. A.
    Khan, Zia U.
    Ahmad, Suhail
    BMC INFECTIOUS DISEASES, 2010, 10
  • [2] Lower sensitivity of serum (1,3)-β-D-glucan for the diagnosis of candidaemia due to Candida parapsilosis
    Mikulska, M.
    Giacobbe, D. R.
    Furfaro, E.
    Mesini, A.
    Marchese, A.
    Del Bono, V.
    Viscoli, C.
    CLINICAL MICROBIOLOGY AND INFECTION, 2016, 22 (07) : 646.e5 - 646.e8
  • [3] Comparison of β-D-Glucan levels between Candida auris and other Candida species at the time of candidaemia: a retrospective study
    Farooqi, Joveria
    Niamatullah, Hammad
    Irfan, Seema
    Zafar, Afia
    Malik, Faisal
    Jabeen, Kauser
    CLINICAL MICROBIOLOGY AND INFECTION, 2021, 27 (10) : 1519.e1 - 1519.e5
  • [4] (1→3)-β-D-Glucan in Cerebrospinal Fluid as a Biomarker for Candida and Aspergillus Infections of the Central Nervous System in Pediatric Patients
    Salvatore, Christine M.
    Chen, Tempe K.
    Toussi, Sima S.
    DeLaMora, Patricia
    Petraitiene, Ruta
    Finkelman, Malcolm A.
    Walsh, Thomas J.
    JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY, 2016, 5 (03) : 277 - 286
  • [5] Comparison of β-1-3-D-Glucan and Candida Mannan Biomarker Assays with Serological Tests for the Diagnosis of Candidemia
    Eades, Christopher P.
    Bakri, Ahmed Rafezzan Bin Ahmed
    Lau, Jeffrey C. Y.
    Moore, Caroline B.
    Novak-Frazer, Lilyann
    Richardson, Malcolm D.
    Rautemaa-Richardson, Riina
    JOURNAL OF FUNGI, 2023, 9 (08)
  • [6] Clinical Performance of the (1,3)-β-D-Glucan Assay in Early Diagnosis of Nosocomial Candida Bloodstream Infections
    Del Bono, Valerio
    Delfino, Emanuele
    Furfaro, Elisa
    Mikulska, Malgorzata
    Nicco, Elena
    Bruzzi, Paolo
    Mularoni, Alessandra
    Bassetti, Matteo
    Viscoli, Claudio
    CLINICAL AND VACCINE IMMUNOLOGY, 2011, 18 (12) : 2113 - 2117
  • [7] (1-3)-β-D-glucan levels in candidiasis infections in the critically ill neonate
    Goudjil, Sabrina
    Kongolo, Guy
    Dusol, Lucie
    Imestouren, Fatiha
    Cornu, Marjorie
    Leke, Andre
    Chouaki, Taieb
    JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, 2013, 26 (01) : 44 - 48
  • [8] Comparison of (1→3)-β-D-Glucan, Mannan/Anti-Mannan Antibodies, and Cand-Tec Candida Antigen as Serum Biomarkers for Candidemia
    Held, Juergen
    Kohlberger, Isabelle
    Rappold, Elfriede
    Grawitz, Andrea Busse
    Haecker, Georg
    JOURNAL OF CLINICAL MICROBIOLOGY, 2013, 51 (04) : 1158 - 1164
  • [9] Clinical value of (1,3)-β-D-glucan, mannan, antimannan IgG and IgM antibodies in diagnosis of invasive candidiasis
    Li, Fengtian
    Yu, Xiaotian
    Ye, Liyan
    Zhou, Guang
    Wang, Leili
    Luo, Yanping
    MEDICAL MYCOLOGY, 2019, 57 (08) : 976 - 986
  • [10] Detection of Galactomannan and (1-3)-β-D-glucan for Early Diagnosis of Invasive Aspergillosis in Hematological Cancer Patients
    Jin, Xin
    Chen, Yifei
    Yu, Nong
    Zuo, Xianghua
    Song, Shiping
    Yin, Xiuyun
    Huang, Yuan
    Zhang, Wei
    Chen, Jiankui
    INTERNATIONAL JOURNAL OF PHARMACOLOGY, 2013, 9 (01) : 86 - 91
12345