Fats, Friends or Foes: Investigating the Role of Short- and Medium-Chain Fatty Acids in Alzheimer's Disease

被引：15
作者：
Ameen, Aishat O. [1 ]
Freude, Kristine [2 ]
Aldana, Blanca, I [1 ]
机构：
[1] Univ Copenhagen, Fac Hlth & Med Sci, Dept Drug Design & Pharmacol, DK-2100 Copenhagen, Denmark
[2] Univ Copenhagen, Fac Hlth & Med Sci, Dept Vet & Anim Sci, DK-1870 Frederiksberg, Denmark
来源：
BIOMEDICINES | 2022年 / 10卷 / 11期
关键词：
neurodegeneration; energy metabolism; hiPSC; octanoic acid; decanoic acid; butyrate; AMYLOID-PRECURSOR-PROTEIN; MOUSE MODEL; TRANSGENIC MICE; KETOGENIC DIET; COGNITIVE IMPAIRMENT; GLUCOSE-METABOLISM; ENERGY-METABOLISM; GUT MICROBIOTA; ADVANCED-STAGE; NEURON LOSS;
D O I：
10.3390/biomedicines10112778
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Characterising Alzheimer's disease (AD) as a metabolic disorder of the brain is gaining acceptance based on the pathophysiological commonalities between AD and major metabolic disorders. Therefore, metabolic interventions have been explored as a strategy for brain energetic rescue. Amongst these, medium-chain fatty acid (MCFA) supplementations have been reported to rescue the energetic failure in brain cells as well as the cognitive decline in patients. Short-chain fatty acids (SCFA) have also been implicated in AD pathology. Due to the increasing therapeutic interest in metabolic interventions and brain energetic rescue in neurodegenerative disorders, in this review, we first summarise the role of SCFAs and MCFAs in AD. We provide a comparison of the main findings regarding these lipid species in established AD animal models and recently developed human cell-based models of this devastating disorder.
引用
收藏
页数：19
相关论文
共 122 条
  • [1] Transgenic pigs as models for translational biomedical research
    Aigner, Bernhard
    Renner, Simone
    Kessler, Barbara
    Klymiuk, Nikolai
    Kurome, Mayuko
    Wuensch, Annegret
    Wolf, Eckhard
    [J]. JOURNAL OF MOLECULAR MEDICINE-JMM, 2010, 88 (07): : 653 - 664
  • [2] Astrocyte metabolism of the medium-chain fatty acids octanoic acid and decanoic acid promotes GABA synthesis in neurons via elevated glutamine supply
    Andersen, Jens, V
    Westi, Emil W.
    Jakobsen, Emil
    Urruticoechea, Nerea
    Borges, Karin
    Aldana, Blanca, I
    [J]. MOLECULAR BRAIN, 2021, 14 (01)
  • [3] Alterations in Cerebral Cortical Glucose and Glutamine Metabolism Precedes Amyloid Plaques in the APPswe/PSEN1dE9 Mouse Model of Alzheimer's Disease
    Andersen, Jens V.
    Christensen, Sofie K.
    Aldana, Blanca I.
    Nissen, Jakob D.
    Tanila, Heikki
    Waagepetersen, Helle S.
    [J]. NEUROCHEMICAL RESEARCH, 2017, 42 (06) : 1589 - 1598
  • [4] Improved cerebral energetics and ketone body metabolism in db/db mice
    Andersen, Jens V.
    Christensen, Sofie K.
    Nissen, Jakob D.
    Waagepetersen, Helle S.
    [J]. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2017, 37 (03) : 1137 - 1147
  • [5] The role of astroglia in Alzheimer's disease: pathophysiology and clinical implications
    Arranz, Amaia M.
    De Strooper, Bart
    [J]. LANCET NEUROLOGY, 2019, 18 (04) : 406 - 414
  • [6] Triheptanoin Supplementation to Ketogenic Diet Curbs Cognitive Impairment in APP/PS1 Mice Used as a Model of Familial Alzheimer's Disease
    Aso, Ester
    Semakova, Jana
    Joda, Laura
    Semak, Vladislav
    Halbaut, Lyda
    Calpena, Ana
    Escolano, Carmen
    Perales, Jose C.
    Ferrer, Isidro
    [J]. CURRENT ALZHEIMER RESEARCH, 2013, 10 (03) : 290 - 297
  • [7] Mechanisms of action for the medium-chain triglyceride ketogenic diet in neurological and metabolic disorders
    Augustin, Katrin
    Khabbush, Aziza
    Williams, Sophie
    Eaton, Simon
    Orford, Michael
    Cross, J. Helen
    Heales, Simon J. R.
    Walker, Matthew C.
    Williams, Robin S. B.
    [J]. LANCET NEUROLOGY, 2018, 17 (01) : 84 - 93
  • [8] Medium Chain Triglycerides induce mild ketosis and may improve cognition in Alzheimer's disease. A systematic review and meta-analysis of human studies
    Avgerinos, Konstantinos I.
    Egan, Josephine M.
    Mattson, Mark P.
    Kapogiannis, Dimitrios
    [J]. AGEING RESEARCH REVIEWS, 2020, 58
  • [9] Dietary and lifestyle guidelines for the prevention of Alzheimer's disease
    Barnard, Neal D.
    Bush, Ashley I.
    Ceccarelli, Antonia
    Cooper, James
    de Jager, Celeste A.
    Erickson, Kirk I.
    Fraser, Gary
    Kesler, Shelli
    Levin, Susan M.
    Lucey, Brendan
    Morris, Martha Clare
    Squitti, Rosanna
    [J]. NEUROBIOLOGY OF AGING, 2014, 35 : S74 - S78
  • [10] The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes
    Benilova, Iryna
    Karran, Eric
    De Strooper, Bart
    [J]. NATURE NEUROSCIENCE, 2012, 15 (03) : 349 - 357
12345678910