Objective. To investigate the relationship of step length to the sex-specific prevalence and worsening of magnetic resonance imaging (MRI)-detected structural damage in the patellofemoral (PF) joint among a cohort of older women and men with or at risk of knee osteoarthritis (OA). Methods. The Multicenter Osteoarthritis Study is a cohort study of persons ages 50-79 years with or at risk of knee OA. Step length was assessed using the GAITRite walkway (CIR Systems) at the 60-month visit, and cartilage damage and bone marrow lesions (BMLs) were graded on MRI at the 60- and 84-month visits. Step length was divided into sex-specific quintiles, and the relationship of step length to the prevalence and worsening of cartilage damage and BMLs in the PF joint was examined using logistic regression, adjusting for age, body mass index (BMI), leg length, and tibiofemoral joint structural damage. Results. In 1,053 knees, 4,094 and 4,083 PF joint subregions were studied for the cartilage and BML analyses, respectively. Mean +/- SD age was 65.6 +/- 8.1 years and mean SD BMI was 29.1 +/- 4.7 kg/m(2); 62% of participants were female. In women, compared to those with the shortest step length, those with the longest step length had 0.62 (95% confidence interval [95% CI] 0.43-0.88) and 0.59 (95% CI 0.40-0.87) times the odds of cartilage damage and BMLs, respectively. There was no cross-sectional association in men, and no longitudinal association in either sex. Conclusion. Women with PF joint structural damage may adapt their gait by shortening their step length, but this may not be sufficient to reduce the risk of worsening damage over time.
机构:
Univ Tasmania, Menzies Inst Med Res, Hobart, Australia
Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Dept Rheumatol, Shanghai, Peoples R ChinaUniv Tasmania, Menzies Inst Med Res, Hobart, Australia
Ma, Canchen
Searle, Daniel
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Univ Tasmania, Menzies Inst Med Res, Hobart, AustraliaUniv Tasmania, Menzies Inst Med Res, Hobart, Australia
Searle, Daniel
Tian, Jing
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Univ Tasmania, Menzies Inst Med Res, Hobart, AustraliaUniv Tasmania, Menzies Inst Med Res, Hobart, Australia
Tian, Jing
Cervo, Mavil May
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Monash Univ, Sch Clin Sci Monash Hlth, Dept Med, Melbourne, Vic, AustraliaUniv Tasmania, Menzies Inst Med Res, Hobart, Australia
Cervo, Mavil May
Scott, David
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机构:
Monash Univ, Sch Clin Sci Monash Hlth, Dept Med, Melbourne, Vic, Australia
Deakin Univ, Sch Exercise & Nutr Sci, Melbourne, AustraliaUniv Tasmania, Menzies Inst Med Res, Hobart, Australia
Scott, David
Hebert, James R.
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h-index: 0
机构:
Univ South Carolina, Canc Prevent & Control Program, Columbia, SC USA
Univ South Carolina, Arnold Sch Publ Hlth, Dept Epidemiol & Biostat, Columbia, SC USAUniv Tasmania, Menzies Inst Med Res, Hobart, Australia
Hebert, James R.
Oddy, Wendy H.
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Univ Tasmania, Menzies Inst Med Res, Hobart, AustraliaUniv Tasmania, Menzies Inst Med Res, Hobart, Australia
Oddy, Wendy H.
Cicuttini, Flavia
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Monash Univ, Dept Epidemiol & Prevent Med, Med Sch, Melbourne, AustraliaUniv Tasmania, Menzies Inst Med Res, Hobart, Australia
Cicuttini, Flavia
Jones, Graeme
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Univ Tasmania, Menzies Inst Med Res, Hobart, AustraliaUniv Tasmania, Menzies Inst Med Res, Hobart, Australia
Jones, Graeme
Pan, Feng
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Univ Tasmania, Menzies Inst Med Res, Hobart, AustraliaUniv Tasmania, Menzies Inst Med Res, Hobart, Australia
机构:
Northeastern Univ, Dept Phys Therapy Movement & Rehabil Sci, 360 Huntington Ave,6B Robinson Hall, Boston, MA 02115 USA
Boston Univ, Sch Med, Clin Epidemiol Res & Training Unit, Boston, MA 02118 USANortheastern Univ, Dept Phys Therapy Movement & Rehabil Sci, 360 Huntington Ave,6B Robinson Hall, Boston, MA 02115 USA
Stefanik, J. J.
Guermazi, A.
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Boston Univ, Sch Med, Dept Radiol, Quantitat Imaging Ctr, Boston, MA 02118 USANortheastern Univ, Dept Phys Therapy Movement & Rehabil Sci, 360 Huntington Ave,6B Robinson Hall, Boston, MA 02115 USA
Guermazi, A.
Roemer, F. W.
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机构:
Boston Univ, Sch Med, Dept Radiol, Quantitat Imaging Ctr, Boston, MA 02118 USA
Univ Erlangen Nurnberg, Dept Radiol, D-91054 Erlangen, GermanyNortheastern Univ, Dept Phys Therapy Movement & Rehabil Sci, 360 Huntington Ave,6B Robinson Hall, Boston, MA 02115 USA
Roemer, F. W.
Peat, G.
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Keele Univ, Res Inst Primary Care & Hlth Sci, Keele ST5 5BG, Staffs, EnglandNortheastern Univ, Dept Phys Therapy Movement & Rehabil Sci, 360 Huntington Ave,6B Robinson Hall, Boston, MA 02115 USA
Peat, G.
Niu, J.
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机构:
Boston Univ, Sch Med, Clin Epidemiol Res & Training Unit, Boston, MA 02118 USANortheastern Univ, Dept Phys Therapy Movement & Rehabil Sci, 360 Huntington Ave,6B Robinson Hall, Boston, MA 02115 USA
Niu, J.
Segal, N. A.
论文数: 0引用数: 0
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Univ Iowa, Dept Epidemiol, Iowa City, IA USA
Univ Kansas, Dept Rehabil Med, Kansas City, KS USANortheastern Univ, Dept Phys Therapy Movement & Rehabil Sci, 360 Huntington Ave,6B Robinson Hall, Boston, MA 02115 USA
Segal, N. A.
Lewis, C. E.
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UAB, Dept Med, Birmingham, AL USANortheastern Univ, Dept Phys Therapy Movement & Rehabil Sci, 360 Huntington Ave,6B Robinson Hall, Boston, MA 02115 USA
Lewis, C. E.
Nevitt, M.
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机构:
UCSF, Dept Epidemiol & Biostat, San Francisco, CA USANortheastern Univ, Dept Phys Therapy Movement & Rehabil Sci, 360 Huntington Ave,6B Robinson Hall, Boston, MA 02115 USA
Nevitt, M.
Felson, D. T.
论文数: 0引用数: 0
h-index: 0
机构:
Boston Univ, Sch Med, Clin Epidemiol Res & Training Unit, Boston, MA 02118 USANortheastern Univ, Dept Phys Therapy Movement & Rehabil Sci, 360 Huntington Ave,6B Robinson Hall, Boston, MA 02115 USA
机构:
Univ Sydney, Discipline Physiotherapy, Fac Hlth Sci, Sydney, NSW, AustraliaUniv Sydney, Discipline Physiotherapy, Fac Hlth Sci, Sydney, NSW, Australia
Kobayashi, Sarah
Peduto, Anthony
论文数: 0引用数: 0
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机构:
Univ Sydney, Westmead Hosp, Dept Radiol, Sydney, NSW, Australia
Univ Sydney, Western Clin Sch, Discipline Med Imaging, Sydney Med Sch, Sydney, NSW, AustraliaUniv Sydney, Discipline Physiotherapy, Fac Hlth Sci, Sydney, NSW, Australia
Peduto, Anthony
Simic, Milena
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Univ Sydney, Discipline Physiotherapy, Fac Hlth Sci, Sydney, NSW, AustraliaUniv Sydney, Discipline Physiotherapy, Fac Hlth Sci, Sydney, NSW, Australia
Simic, Milena
Fransen, Marlene
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Univ Sydney, Discipline Physiotherapy, Fac Hlth Sci, Sydney, NSW, AustraliaUniv Sydney, Discipline Physiotherapy, Fac Hlth Sci, Sydney, NSW, Australia
Fransen, Marlene
Refshauge, Kathryn
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h-index: 0
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Univ Sydney, Discipline Physiotherapy, Fac Hlth Sci, Sydney, NSW, AustraliaUniv Sydney, Discipline Physiotherapy, Fac Hlth Sci, Sydney, NSW, Australia
Refshauge, Kathryn
Mah, Jean
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Westmead Hosp, Dept Imaging, Westmead, NSW, AustraliaUniv Sydney, Discipline Physiotherapy, Fac Hlth Sci, Sydney, NSW, Australia
Mah, Jean
Pappas, Evangelos
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h-index: 0
机构:
Univ Sydney, Discipline Physiotherapy, Fac Hlth Sci, Sydney, NSW, AustraliaUniv Sydney, Discipline Physiotherapy, Fac Hlth Sci, Sydney, NSW, Australia
机构:
Boston Univ, Sch Med, Boston, MA 02118 USABoston Univ, Sch Med, Boston, MA 02118 USA
Stefanik, J. J.
Niu, J.
论文数: 0引用数: 0
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机构:
Boston Univ, Sch Med, Boston, MA 02118 USABoston Univ, Sch Med, Boston, MA 02118 USA
Niu, J.
Gross, K. D.
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机构:
Boston Univ, Sch Med, Boston, MA 02118 USA
Massachusetts Gen Hosp, Inst Hlth Profess, Boston, MA 02114 USABoston Univ, Sch Med, Boston, MA 02118 USA
Gross, K. D.
Roemer, F. W.
论文数: 0引用数: 0
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机构:
Boston Univ, Sch Med, Boston, MA 02118 USA
Klinikum Augsburg, Augsburg, GermanyBoston Univ, Sch Med, Boston, MA 02118 USA
Roemer, F. W.
Guermazi, A.
论文数: 0引用数: 0
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机构:
Boston Univ, Sch Med, Boston, MA 02118 USABoston Univ, Sch Med, Boston, MA 02118 USA
Guermazi, A.
Felson, D. T.
论文数: 0引用数: 0
h-index: 0
机构:
Boston Univ, Sch Med, Boston, MA 02118 USABoston Univ, Sch Med, Boston, MA 02118 USA
机构:
Boston Univ, Sch Med, Sect Rheumatol, Boston, MA 02118 USABoston Univ, Sch Med, Sect Rheumatol, Boston, MA 02118 USA
Liew, Jean. W. W.
Rabasa, Gabriela
论文数: 0引用数: 0
h-index: 0
机构:
Boston Univ, Sch Med, Sect Rheumatol, Boston, MA 02118 USABoston Univ, Sch Med, Sect Rheumatol, Boston, MA 02118 USA
Rabasa, Gabriela
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LaValley, Michael
Collins, Jamie
论文数: 0引用数: 0
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机构:
Brigham & Womens Hosp, Orthoped & Arthrit Ctr Outcomes Res, Dept Orthoped Surg, Boston, MA USA
Harvard Med Sch, Boston, MA USABoston Univ, Sch Med, Sect Rheumatol, Boston, MA 02118 USA
Collins, Jamie
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Stefanik, Joshua
Roemer, Frank. W. W.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Klinikum Erlangen, Dept Radiol, Erlangen, Germany
Friedrich Alexander Univ Erlangen Nurnberg FAU, Erlangen, Germany
Boston Univ, Sch Med, Dept Radiol, Boston, MA USABoston Univ, Sch Med, Sect Rheumatol, Boston, MA 02118 USA
Roemer, Frank. W. W.
Guermazi, Ali
论文数: 0引用数: 0
h-index: 0
机构:
Boston Univ, Dept Radiol, Sch Med, Boston, MA USA
VA Boston Healthcare Syst, Dept Radiol, Boston, MA USABoston Univ, Sch Med, Sect Rheumatol, Boston, MA 02118 USA
Guermazi, Ali
Lewis, Cora. E. E.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Alabama Birmingham, Birmingham, AL USABoston Univ, Sch Med, Sect Rheumatol, Boston, MA 02118 USA
Lewis, Cora. E. E.
Nevitt, Michael
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, San Francisco, CA USABoston Univ, Sch Med, Sect Rheumatol, Boston, MA 02118 USA
Nevitt, Michael
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Torner, James
Felson, David
论文数: 0引用数: 0
h-index: 0
机构:
Boston Univ, Sch Med, Sect Rheumatol, Boston, MA 02118 USABoston Univ, Sch Med, Sect Rheumatol, Boston, MA 02118 USA