Thrombo-Inflammation in Cardiovascular Disease: An Expert Consensus Document from the Third Maastricht Consensus Conference on Thrombosis

被引：64

作者：

d'Alessandro, Elisa ^{[1
,2
,3
]}

Becker, Christian ^{[4
]}

Bergmeier, Wolfgang ^{[5
]}

Bode, Christoph ^{[6
]}

Bourne, Joshua H. ^{[7
]}

Brown, Helena ^{[8
]}

Buller, Harry R. ^{[9
]}

ten Cate-Hoek, Arina J. ^{[1
,2
,3
,33
,34
]}

ten Cate, Vincent ^{[10
]}

van Cauteren, Yvonne J. M. ^{[3
,11
]}

Cheung, Yam F. H. ^{[12
]}

Cleuren, Audrey ^{[13
]}

Coenen, Danielle ^{[3
,14
]}

Crijns, Harry J. G. M. ^{[3
,11
]}

de Simone, Ilaria ^{[3
,14
]}

Dolleman, Sophie C. ^{[15
,16
]}

Klein, Christine Espinola ^{[17
]}

Fernandez, Delia I. ^{[3
,14
]}

Granneman, Lianne ^{[18
]}

van t Hof, Arnoud ^{[3
,11
,33
,34
]}

Henke, Peter ^{[19
]}

Henskens, Yvonne M. C. ^{[3
,20
]}

Huang, Jingnan ^{[3
,14
]}

Jennings, Lisa K. ^{[21
,22
]}

Jooss, Natalie ^{[3
,14
]}

Karel, Mieke ^{[3
,14
]}

van den Kerkhof, Danique ^{[3
,14
]}

Klok, Frederik A. ^{[23
]}

Kremers, Bram ^{[1
,2
,3
]}

Laemmle, Bernhard ^{[24
,25
,26
,27
]}

Leader, Avi ^{[1
,2
,3
,28
]}

Lundstrom, Annika ^{[29
,33
,34
]}

Mackman, Nigel ^{[30
]}

Mannucci, Pier M. ^{[31
]}

Maqsood, Zahra ^{[8
]}

van der Meijden, Paola E. J. ^{[1
,2
,3
,14
]}

van Moorsel, Marc ^{[18
]}

Moran, Luis A. ^{[32
]}

Morser, John ^{[33
,34
]}

van Mourik, Manouk ^{[3
,11
]}

Navarro, Stefano ^{[8
]}

Neagoe, Raluca A. I. ^{[7
]}

Olie, Renske H. ^{[1
,2
,3
]}

van Paridon, Pauline ^{[1
,2
,3
]}

Posma, Jens ^{[1
,2
,3
]}

Provenzale, Isabella ^{[3
,14
]}

Reitsma, Pieter H. ^{[15
,16
]}

Scaf, Billy ^{[1
,2
,3
]}

Schurgers, Leon ^{[3
,14
]}

Seelig, Jaap ^{[1
,2
,3
,35
]}

机构：

[1] Maastricht Univ, Med Ctr, Dept Biochem & Internal Med, Lab Clin Thrombosis & Hemostasis, Maastricht, Netherlands

[2] Maastricht Univ, Med Ctr, Thrombosis Expert Ctr, Maastricht, Netherlands

[3] CARIM Sch Cardiovasc Dis, Maastricht, Netherlands

[4] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Dept Dermatol, Mainz, Germany

[5] Univ N Carolina, Dept Biochem & Biophys, McAllister Heart Inst, Chapel Hill, NC 27515 USA

[6] Univ Freiburg, Univ Heart Ctr Freiburg, Dept Cardiol & Angiol 1, Med Ctr, Bad Krozingen, Germany

[7] Univ Birmingham, Coll Med & Dent Sci, Inst Cardiovasc Sci, Birmingham, W Midlands, England

[8] DFG Forschungszentrum Expt Biomed, Rudolf Virchov Zentrum, Wurzburg, Germany

[9] Univ Amsterdam, Med Ctr, Dept Vasc Med, Amsterdam, Netherlands

[10] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Ctr Thrombosis & Hemostasis, Clin Epidemiol & Syst Med, Mainz, Germany

[11] Maastricht Univ, Med Ctr, Dept Cardiol, Maastricht, Netherlands

[12] Leibniz Inst Analyt Wissensch ISAS, Dortmund, Germany

[13] Univ Michigan, Life Sci Inst, Ann Arbor, MI 48109 USA

[14] Maastricht Univ, Dept Biochem, Maastricht, Netherlands

[15] Leiden Univ, Med Ctr, Dept Internal Med Nephrol, Leiden, Netherlands

[16] Leiden Univ, Med Ctr, Einthoven Lab Expt Vasc & Regenerat Med, Leiden, Netherlands

[17] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Ctr Cardiol Cardiol 1, Mainz, Germany

[18] Univ Med Ctr Utrecht, Dept Clin Chem & Haematol, Utrecht, Netherlands

[19] Michigan Med Vasc Surg Clin, Ctr Cardiovasc, Ann Arbor, MI USA

[20] Maastricht Univ, Med Ctr, Cent Diagnost Lab, Maastricht, Netherlands

[21] CirQuest Labs LLC, Memphis, TN USA

[22] Univ Tennessee, Ctr Hlth Sci, Memphis, TN 38163 USA

[23] Leiden Univ, Med Ctr, Dept Thrombosis & Hemostasis, Leiden, Netherlands

[24] Univ Bern, Bern Univ Hosp, Dept Hematol, Inselspital, Bern, Switzerland

[25] Univ Bern, Bern Univ Hosp, Cent Hematol Lab, Inselspital, Bern, Switzerland

[26] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Ctr Thrombosis & Hemostasis, Mainz, Germany

[27] UCL, Haemostasis Res Unit, London, England

[28] Rabin Med Ctr, Dept Hematol, Petah Tiqwa, Israel

[29] Karolinska Inst, Danderyd Hosp, Dept Clin Sci, Div Internal Med, Stockholm, Sweden

[30] Univ N Carolina, UNC McAllister Heart Inst, Dept Med, Chapel Hill, NC 27515 USA

[31] IRCCS Ca Granda Maggiore Policlin Hosp Fdn, Sci Direct, Milan, Italy

[32] Univ Santiago de Compostela, CIMUS, Santiago De Compostela, Spain

[33] Stanford Univ, Sch Med, Div Hematol, Palo Alto, CA 94304 USA

[34] Palo Alto Vet Adm Hlth Care Syst, Palo Alto, CA USA

[35] Rijnstate Ziekenhuis, Dept Cardiol, Arnhem, Netherlands

[36] Uppsala Univ, Clin Chem & Sci Life Lab, Dept Med Sci, Uppsala, Sweden

[37] Charite, Ctr Stroke Res Berlin, Berlin, Germany

[38] Ludwig Maximilian Univ Munich, Inst Cardiovasc Prevent, Munich, Germany

[39] Univ Reading, Sch Biol Sci, Inst Cardiovasc & Metab Res, Reading, Berks, England

[40] Univ Sheffield, Dept Infect Immun & Cardiovasc Dis, Sheffield, S Yorkshire, England

[41] McMaster Univ, Dept Med, Div Hematol & Thromboembolism, Hamilton, ON, Canada

[42] McMaster Univ, Thrombosis & Atherosclerosis Res Inst, Hamilton, ON, Canada

[43] Univ Bern, Bern Univ Hosp, Inselspital, Dept Haematol, Bern, Switzerland

[44] Univ Bern, Bern Univ Hosp, Inselspital, Cent Haematol Lab, Bern, Switzerland

[45] Univ Bern, Dept BioMed Res, Bern, Switzerland

来源：

THROMBOSIS AND HAEMOSTASIS | 2020年 / 120卷 / 04期

关键词：

thrombosis; inflammation; coagulation; pulmonary embolism; myocardial infarction; stroke; platelets; ACTIVATABLE FIBRINOLYSIS INHIBITOR; DEEP-VEIN THROMBOSIS; NEUTROPHIL EXTRACELLULAR TRAPS; PERIPHERAL ARTERY-DISEASE; ACUTE CORONARY SYNDROMES; SUBCLINICAL LEAFLET THROMBOSIS; CATHETER-DIRECTED THROMBOLYSIS; ISCHEMIA-REPERFUSION INJURY; VENOUS THROMBOSIS; TISSUE FACTOR;

D O I：

10.1055/s-0040-1708035

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Thrombo-inflammation describes the complex interplay between blood coagulation and inflammation that plays a critical role in cardiovascular diseases. The third Maastricht Consensus Conference on Thrombosis assembled basic, translational, and clinical scientists to discuss the origin and potential consequences of thrombo-inflammation in the etiology, diagnostics, and management of patients with cardiovascular disease, including myocardial infarction, stroke, and peripheral artery disease. This article presents a state-of-the-art reflection of expert opinions and consensus recommendations regarding the following topics: (1) challenges of the endothelial cell barrier; (2) circulating cells and thrombo-inflammation, focused on platelets, neutrophils, and neutrophil extracellular traps; (3) procoagulant mechanisms; (4) arterial vascular changes in atherogenesis; attenuating atherosclerosis and ischemia/reperfusion injury; (5) management of patients with arterial vascular disease; and (6) pathogenesis of venous thrombosis and late consequences of venous thromboembolism.

引用

页码：538 / 564

页数：27

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