Polygenic Score for Body Mass Index Is Associated with Disordered Eating in a General Population Cohort

被引:29
作者
Abdulkadir, Mohamed [1 ]
Herle, Moritz [2 ,3 ]
De Stavola, Bianca L. [2 ]
Huebel, Christopher [4 ,5 ,6 ]
Ferreira, Diana L. Santos [7 ,8 ]
Loos, Ruth J. F. [9 ]
Bryant-Waugh, Rachel [10 ]
Bulik, Cynthia M. [11 ,12 ]
Micali, Nadia [1 ,2 ,13 ]
机构
[1] Univ Geneva, Fac Med, Dept Psychiat, CH-1205 Geneva, Switzerland
[2] UCL, Great Ormond St Inst Child Hlth, London WC1N 1EH, England
[3] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Biostat & Hlth Informat, London SE5 8AB, England
[4] Kings Coll London, Inst Psychiat Psychol & Neurosci, Social Genet & Dev Psychiat Ctr, London SE5 8AF, England
[5] South London & Maudsley Hosp, Biomed Res Ctr, UK Natl Inst Hlth Res NIHR, London SE5 8AF, England
[6] Karolinska Inst, Dept Med Epidemiol & Biostat, SE-17177 Stockholm, Sweden
[7] Univ Bristol, Med Res Council Integrat Epidemiol, Bristol BS8 2BN, Avon, England
[8] Univ Bristol, Bristol Med Sch, Populat Hlth Sci, Bristol BS8 2PS, Avon, England
[9] Icahn Sch Med Mt Sinai, Mindich Child Hlth & Dev Inst, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA
[10] Maudsley Hosp & Inst Psychiat, Maudsley Ctr Child & Adolescent Eating Disorders, Michael Rutter Ctr Children & Young People, London SE5 8AZ, England
[11] Univ North Carolina Chapel Hill, Dept Psychiat, Chapel Hill, NC 27599 USA
[12] Univ North Carolina Chapel Hill, Dept Nutr, Chapel Hill, NC 27599 USA
[13] Univ Geneva, Dept Pediat Gynecol & Obstet, CH-1205 Geneva, Switzerland
基金
瑞典研究理事会; 英国医学研究理事会; 英国惠康基金;
关键词
Avon Longitudinal Study of Parents and Children (ALSPAC); body mass index; disordered eating behaviors; disordered eating cognitions; polygenic scores; THIN-IDEAL; WEIGHT; ADOLESCENTS; RISK; OBESITY; BEHAVIORS; DISSATISFACTION; OUTCOMES; TRAJECTORIES; PREVALENCE;
D O I
10.3390/jcm9041187
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Disordered eating (DE) is common and is associated with body mass index (BMI). We investigated whether genetic variants for BMI were associated with DE. Methods: BMI polygenic scores (PGS) were calculated for participants of the Avon Longitudinal Study of Parents and Children (ALSPAC; N = 8654) and their association with DE tested. Data on DE behaviors (e.g., binge eating and compensatory behaviors) were collected at ages 14, 16, 18 years, and DE cognitions (e.g., body dissatisfaction) at 14 years. Mediation analyses determined whether BMI mediated the association between the BMI-PGS and DE. Results: The BMI-PGS was positively associated with fasting (OR = 1.42, 95% CI = 1.25, 1.61), binge eating (OR = 1.28, 95% CI = 1.12, 1.46), purging (OR = 1.20, 95% CI = 1.02, 1.42), body dissatisfaction (Beta = 0.99, 95% CI = 0.77, 1.22), restrained eating (Beta = 0.14, 95% CI = 0.10, 1.17), emotional eating (Beta = 0.21, 95% CI = 0.052, 0.38), and negatively associated with thin ideal internalization (Beta = -0.15, 95% CI = -0.23, -0.07) and external eating (Beta = -0.19, 95% CI = -0.30, -0.09). These associations were mainly mediated by BMI. Conclusions: Genetic variants associated with BMI are also associated with DE. This association was mediated through BMI suggesting that weight potentially sits on the pathway from genetic liability to DE.
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页数:17
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