Clinical neurocardiology defining the value of neuroscience-based cardiovascular therapeutics

被引：232

作者：

Shivkumar, Kalyanam ^{[1
,2
]}

Ajijola, Olujimi A. ^{[1
,2
]}

Anand, Inder ^{[3
]}

Armour, J. Andrew ^{[1
,2
]}

Chen, Peng-Sheng ^{[4
]}

Esler, Murray ^{[5
]}

De Ferrari, Gaetano M. ^{[6
]}

Fishbein, Michael C. ^{[7
]}

Goldberger, Jeffrey J. ^{[8
]}

Harper, Ronald M. ^{[9
,10
]}

Joyner, Michael J. ^{[11
]}

Khalsa, Sahib S. ^{[12
]}

Kumar, Rajesh ^{[13
,14
]}

Lane, Richard ^{[15
]}

Mahajan, Aman ^{[16
]}

Po, Sunny ^{[17
,18
]}

Schwartz, Peter J. ^{[19
]}

Somers, Virend K. ^{[11
]}

Valderrabano, Miguel ^{[20
,21
]}

Vaseghi, Marmar ^{[1
,2
]}

Zipes, Douglas P. ^{[22
]}

机构：

[1] Univ Calif Los Angeles, Cardiac Arrhythmia Ctr, 100 UCLA Med Plaza,Suite 660, Los Angeles, CA USA

[2] Univ Calif Los Angeles, Neurocardiol Res Ctr Excellence, 100 UCLA Med Plaza,Suite 660, Los Angeles, CA USA

[3] Univ Minnesota, Sch Med, Dept Cardiol, Minneapolis, MN 55455 USA

[4] Indiana Univ Sch Med, Krannert Inst Cardiol, Indianapolis, IN 46202 USA

[5] Baker IDI Heart & Diabet Inst, Melbourne, Vic, Australia

[6] Univ Pavia, Dept Mol Med, Pavia, Italy

[7] Univ Calif Los Angeles, David Geffen Sch Med, Dept Pathol & Lab Med, 100 UCLA Med Plaza,Suite 660, Los Angeles, CA 90095 USA

[8] Univ Miami, Miller Sch Med, Div Cardiol, Miami, FL 33136 USA

[9] Univ Calif Los Angeles, Dept Neurobiol, 100 UCLA Med Plaza,Suite 660, Los Angeles, CA USA

[10] Univ Calif Los Angeles, Brain Res Inst, 100 UCLA Med Plaza,Suite 660, Los Angeles, CA 90024 USA

[11] Mayo Clin & Mayo Fdn, Div Cardiovasc Dis, Rochester, MN 55905 USA

[12] Laureate Inst Brain Res, Tulsa, OK USA

[13] Univ Calif Los Angeles, David Geffen Sch Med, Dept Anesthesiol, 100 UCLA Med Plaza,Suite 660, Los Angeles, CA 90095 USA

[14] Univ Calif Los Angeles, David Geffen Sch Med, Dept Radiol Sci, 100 UCLA Med Plaza,Suite 660, Los Angeles, CA 90095 USA

[15] Univ Arizona, Coll Med, Dept Psychiat, Tucson, AZ USA

[16] Univ Calif Los Angeles, Dept Anesthesia, 100 UCLA Med Plaza,Suite 660, Los Angeles, CA USA

[17] Univ Oklahoma, Hlth Sci Ctr, Heart Rhythm Inst, Oklahoma City, OK USA

[18] Univ Tulsa, Oxley Coll Hlth Sci, Tulsa, OK 74104 USA

[19] IRCCS Inst Auxol Italiano, Ctr Cardiac Arrhythmias Genet Origin, Ctr Diagnost Ricerrca San Carlo, Milan, Italy

[20] Houston Methodist Hosp, Methodist DeBakey Heart & Vasc Ctr, Houston, TX USA

[21] Houston Methodist Hosp, Methodist Hosp Res Inst, Houston, TX USA

[22] Indiana Univ Sch Med, Indianapolis, IN 46202 USA

来源：

JOURNAL OF PHYSIOLOGY-LONDON | 2016年 / 594卷 / 14期

基金：

英国医学研究理事会; 美国国家卫生研究院;

关键词：

VAGUS-NERVE-STIMULATION; SUDDEN CARDIAC DEATH; THORACIC EPIDURAL-ANESTHESIA; OBSTRUCTIVE SLEEP-APNEA; HEART-RATE-VARIABILITY; POLYMORPHIC VENTRICULAR-TACHYCARDIA; RADIOFREQUENCY CATHETER ABLATION; PAROXYSMAL ATRIAL-FIBRILLATION; REDUCES ACETYLCHOLINE-RELEASE; ACUTE MYOCARDIAL-INFARCTION;

D O I：

10.1113/JP271870

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The autonomic nervous system regulates all aspects of normal cardiac function, and is recognized to play a critical role in the pathophysiology of many cardiovascular diseases. As such, the value of neuroscience-based cardiovascular therapeutics is increasingly evident. This White Paper reviews the current state of understanding of human cardiac neuroanatomy, neurophysiology, pathophysiology in specific disease conditions, autonomic testing, risk stratification, and neuromodulatory strategies to mitigate the progression of cardiovascular diseases.

引用

页码：3911 / 3954

页数：44

共 439 条

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