One-pot synthesis of α-aminophosphonates catalyzed by antimony trichloride adsorbed on alumina

被引：99

作者：

Ambica ^{[1
]}

Kumar, Satish ^{[1
]}

Taneja, Subhash C. ^{[2
]}

Hundal, Maninder S. ^{[3
]}

Kapoor, Kamal K. ^{[1
]}

机构：

[1] Univ Jammu, Dept Chem, Jammu 180006, India

[2] Indian Inst Integrat Med, Bioorgan Chem Div, Jammu 180001, India

[3] Guru Nanak Dev Univ, Dept Chem, Amritsar 143005, Punjab, India

来源：

TETRAHEDRON LETTERS | 2008年 / 49卷 / 14期

关键词：

sbCl(3)/Al2O3; alpha-amino acid; alpha-aminophosphonate; solid supported reagents; recyclability;

D O I：

10.1016/j.tetlet.2008.02.047

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

SbCl3 adsorbed on Al2O3 is found to be an efficient and recyclable catalyst in promoting three-component coupling reactions of aldehydes (aromatic and aliphatic), amines (aryl amines, aliphatic amines and esters of S-cc-amino acids) and dialkylphosphites to afford the corresponding alpha-aminophosphonates in high yields. The ethyl ester of S-phenylalanine was observed to yield the corresponding ot-aminophosphonate with S,S-diastereoisomer formed in dominance over the S,R-diastereoisomer. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：2208 / 2212

页数：5

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