Effect of Simulated Gastrointestinal Digestion on Sialic Acid and Gangliosides Present in Human Milk and Infant Formulas

被引：27

作者：

Lacomba, Ramon ^{[1
]}

Salcedo, Jaime ^{[1
]}

Alegria, Arnparo ^{[1
]}

Barbera, Reyes ^{[1
]}

Hueso, Pablo ^{[2
]}

Matencio, Esther ^{[3
]}

Jeslis Lagardat, M. ^{[1
]}

机构：

[1] Univ Valencia, Dept Nutr & Food Chem, Fac Pharm, E-46100 Valencia, Spain

[2] Univ Salamanca, Dept Biochem & Mol Biol, Fac Biol, Salamanca 37007, Spain

[3] Hero Inst Infant Nutr, Murcia 30820, Spain

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2011年 / 59卷 / 10期

关键词：

Sialic acid; gangliosides; bioavailabity; bioaccessibility; in vitro gastrointestinal digestion; infant formula; human milk; BOVINE-MILK; QUANTITATIVE ESTIMATION; DIETARY GANGLIOSIDE; RAT; LACTATION; METABOLISM; BRAIN; MOUSE; EXCRETION;

D O I：

10.1021/jf200663k

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

The effects of simulated gastrointestinal digestion upon sialic acid and gangliosides in infant and follow-on formulas and human milk, as well as their bioaccessibility, have been evaluated. The gastric stage is the step that causes a greater decrease in sialic acid and ganglioside contents. The intestinal stage only decreases the total and individual contents of gangliosides. After gastrointestinal digestion, neither sialic acid nor gangliosides were found in the nonbioaccessible fraction. The highest bioaccessibility (100 x content in soluble fraction after gastrointestinal digestion/total content) of sialic acid is found in human milk (87%), followed by infant formula (77%) and follow-on formula (16%). In the case of gangliosides, the highest bioaccessibility is present in the follow-on formula (51%), followed by human milk (29%) and infant formula (5%).

引用

页码：5755 / 5762

页数：8

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