Perifovea retinal thickness as an ophthalmic biomarker for mild cognitive impairment and early Alzheimer's disease

被引：26
作者：
Tao, Rui [1 ]
Lu, Zhaozeng [1 ]
Ding, Ding [2 ,3 ]
Fu, Shuhao [1 ]
Hong, Zhen [2 ,3 ]
Liang, Xiaoniu [2 ]
Zheng, Li [2 ]
Xiao, Yiqin [1 ]
Zhao, Qianhua [2 ,3 ]
机构：
[1] Fudan Univ, Huashan Hosp, Dept Ophthalmol, Shanghai, Peoples R China
[2] Fudan Univ, Huashan Hosp, Dept Neurol, Shanghai, Peoples R China
[3] Fudan Univ, Huashan Hosp, Natl Clin Res Ctr Aging & Med, Shanghai, Peoples R China
来源：
ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING | 2019年 / 11卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Alzheimer's disease; Mild cognitive impairment; Retinal thickness; Brain atrophy; Biomarker;
D O I：
10.1016/j.dadm.2019.04.003
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Introduction The aim of this study was to investigate retinal thickness as a biomarker for identifying patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD). Methods The retinal thickness, utilizing the spectral domain optical coherence tomography, was compared among 73 patients with AD, 51 patients with MCI, 67 cognitive normal control (NC) subjects. Results The retinal thickness of ganglion cell complex and peripapillary retinal nerve fiber layer decreased in both AD and MCI patients, in comparison with NC subjects (AD vs. NC, P < .01; MCI vs. NC, P < .01). The inner retinal layers in macular area in MCI exhibited significant thinning compared with NC (P < .001). Remarkable association was found between the retinal thickness and brain volume (P < .05). Better correlation was seen between the inner perifovea retinal thickness and the hippocampal and entorhinal cortex volume (r: 0.427-0.644, P < .01). Discussion The retinal thickness, especially the inner retinal layer thickness, is a potentially early AD marker indicating neurodegeneration.
引用
收藏
页码：405 / 414
页数：10
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