Perifovea retinal thickness as an ophthalmic biomarker for mild cognitive impairment and early Alzheimer's disease

被引：26
作者：
Tao, Rui [1 ]
Lu, Zhaozeng [1 ]
Ding, Ding [2 ,3 ]
Fu, Shuhao [1 ]
Hong, Zhen [2 ,3 ]
Liang, Xiaoniu [2 ]
Zheng, Li [2 ]
Xiao, Yiqin [1 ]
Zhao, Qianhua [2 ,3 ]
机构：
[1] Fudan Univ, Huashan Hosp, Dept Ophthalmol, Shanghai, Peoples R China
[2] Fudan Univ, Huashan Hosp, Dept Neurol, Shanghai, Peoples R China
[3] Fudan Univ, Huashan Hosp, Natl Clin Res Ctr Aging & Med, Shanghai, Peoples R China
来源：
ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING | 2019年 / 11卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Alzheimer's disease; Mild cognitive impairment; Retinal thickness; Brain atrophy; Biomarker;
D O I：
10.1016/j.dadm.2019.04.003
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Introduction The aim of this study was to investigate retinal thickness as a biomarker for identifying patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD). Methods The retinal thickness, utilizing the spectral domain optical coherence tomography, was compared among 73 patients with AD, 51 patients with MCI, 67 cognitive normal control (NC) subjects. Results The retinal thickness of ganglion cell complex and peripapillary retinal nerve fiber layer decreased in both AD and MCI patients, in comparison with NC subjects (AD vs. NC, P < .01; MCI vs. NC, P < .01). The inner retinal layers in macular area in MCI exhibited significant thinning compared with NC (P < .001). Remarkable association was found between the retinal thickness and brain volume (P < .05). Better correlation was seen between the inner perifovea retinal thickness and the hippocampal and entorhinal cortex volume (r: 0.427-0.644, P < .01). Discussion The retinal thickness, especially the inner retinal layer thickness, is a potentially early AD marker indicating neurodegeneration.
引用
收藏
页码：405 / 414
页数：10
相关论文
共 42 条
  • [1] Retinal alterations in mild cognitive impairment and Alzheimer's disease: an optical coherence tomography study
    Ascaso, Francisco J.
    Cruz, Nancy
    Modrego, Pedro J.
    Lopez-Anton, Raul
    Santabarbara, Javier
    Pascual, Luis F.
    Lobo, Antonio
    Cristobal, Jose A.
    [J]. JOURNAL OF NEUROLOGY, 2014, 261 (08) : 1522 - 1530
  • [2] Becker RE, 2008, J ALZHEIMERS DIS, V15, P303
  • [3] CSF phosphorylated tau protein correlates with neocortical neurofibrillary pathology in Alzheimer's disease
    Buerger, Katharina
    Ewers, Michael
    Pirttila, Tuula
    Zinkowski, Raymond
    Alafuzoff, Irina
    Teipel, Stefan J.
    DeBernardis, John
    Kerkman, Daniel
    McCulloch, Cheryl
    Soininen, Hilkka
    Hampel, Harald
    [J]. BRAIN, 2006, 129 : 3035 - 3041
  • [4] Mild cognitive impairment -: Long-term course of four clinical subtypes
    Busse, A.
    Hensel, A.
    Guehne, U.
    Angermeyer, M. C.
    Riedel-Heller, S. G.
    [J]. NEUROLOGY, 2006, 67 (12) : 2176 - 2185
  • [5] Retinal thinning is uniquely associated with medial temporal lobe atrophy in neurologically normal older adults
    Casaletto, Kaitlin B.
    Ward, Michael E.
    Baker, Nicholas S.
    Bettcher, Brianne M.
    Gelfand, Jeffrey M.
    Li, Yaqiao
    Chen, Robert
    Dutt, Shubir
    Miller, Bruce
    Kramer, Joel H.
    Green, Ari J.
    [J]. NEUROBIOLOGY OF AGING, 2017, 51 : 141 - 147
  • [6] Neuropsychiatric symptoms are associated with increased risks of progression to dementia: a 2-year prospective study of 321 Chinese older persons with mild cognitive impairment
    Chan, Wai Chi
    Lam, Linda C. W.
    Tam, Cindy W. C.
    Lui, Victor W. C.
    Leung, Grace T. Y.
    Lee, Allen T. C.
    Chan, Sandra S. M.
    Fung, Ada W. T.
    Chiu, Helen F. K.
    Chan, Wai Man
    [J]. AGE AND AGEING, 2011, 40 (01) : 30 - 35
  • [7] Retinal Ganglion Cell Analysis Using High-Definition Optical Coherence Tomography in Patients with Mild Cognitive Impairment and Alzheimer's Disease
    Cheung, Carol Yim-Lui
    Ong, Yi Ting
    Hilal, Saima
    Ikram, M. Kamran
    Low, Sally
    Ong, Yi Lin
    Venketasubramanian, N.
    Yap, Philip
    Seow, Dennis
    Chen, Christopher Li Hsian
    Wong, Tien Yin
    [J]. JOURNAL OF ALZHEIMERS DISEASE, 2015, 45 (01) : 45 - 56
  • [8] TOPOGRAPHY OF GANGLION-CELLS IN HUMAN RETINA
    CURCIO, CA
    ALLEN, KA
    [J]. JOURNAL OF COMPARATIVE NEUROLOGY, 1990, 300 (01) : 5 - 25
  • [9] den Haan Jurre, 2018, Alzheimers Dement (Amst), V10, P49, DOI 10.1016/j.dadm.2017.10.005
  • [10] Ganglion cell layer measurements correlate with disease severity in patients with Alzheimer's disease
    den Haan, Jurre
    Balk, Lisanne J.
    Verbraak, Frank D.
    [J]. ACTA OPHTHALMOLOGICA, 2018, 96 (02) : e265 - e266
12345