Comment on 'YcgC represents a new protein deacetylase family in prokaryotes'

被引：11

作者：

Kremer, Magdalena ^{[1
,2
]}

Kuhlmann, Nora ^{[1
,2
]}

Lechner, Marius ^{[1
,2
]}

Baldus, Linda ^{[1
,2
]}

Lammers, Michael ^{[1
,2
,3
]}

机构：

[1] Univ Cologne, Inst Genet, Cologne, Germany

[2] Univ Cologne, Cologne Excellence Cluster Cellular Stress Respon, Cologne, Germany

[3] Ernst Moritz Arndt Univ Greifswald, Inst Biochem Synthet & Struct Biochem, Greifswald, Germany

来源：

ELIFE | 2018年 / 7卷

关键词：

LYSINE ACETYLATION; INSIGHTS; REVEALS; SIRT6; COBB;

D O I：

10.7554/eLife.37798

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Lysine acetylation is a post-translational modification that is conserved from bacteria to humans. It is catalysed by the activities of lysine acetyltransferases, which use acetyl-CoA as the acetyl-donor molecule, and lysine deacetylases, which remove the acetyl moiety. Recently, it was reported that YcgC represents a new prokaryotic deacetylase family with no apparent homologies to existing deacetylases (Tu et al., 2015). Here we report the results of experiments which demonstrate that YcgC is not a deacetylase.

引用

页数：12

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