Recent progress in capillary electrophoretic analysis of amino acid enantiomers

被引：98
作者：
Kitagawa, Fumihiko [1 ]
Otsuka, Koji [1 ]
机构：
[1] Kyoto Univ, Grad Sch Engn, Dept Chem Mat, Nishikyo Ku, Kyoto 6158510, Japan
来源：
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES | 2011年 / 879卷 / 29期
基金：
日本学术振兴会;
关键词：
Enantioseparation; Amino acids; Capillary electrophoresis; Electrokinetic chromatography; Capillary electrochromatography; Cyclodextrins; MICELLAR ELECTROKINETIC CHROMATOGRAPHY; MONOLITHIC SILICA COLUMN; LIGAND-EXCHANGE CE; STRUCTURE-ENANTIOSELECTIVITY RELATIONSHIP; BETA-CYCLODEXTRIN DERIVATIVES; CHIRAL SEPARATION PRINCIPLES; BUTYL CARBAMOYLATED QUININE; PARTICLE-LOADED MONOLITHS; ALPHA-HYDROXY ACIDS; SINGLE-ISOMER;
D O I：
10.1016/j.jchromb.2011.03.016
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
This review highlights recent progresses in capillary electrophoresis (CE) analysis of amino acid enantiomers in the last decade. Various chiral selectors including cyclodextrins (CDs), bile salts, crown ethers, cinchona alkaloids, metal-chiral amino acid complexes, macrocyclic antibiotics and proteins have been employed to separate amino acid enantiomers. In the CE analysis of amino acids, the selection of the separation mode is one of the most important issues to obtain good resolution of target enantiomers. Among several separation modes. CD-modified capillary zone electrophoresis (CD-CZE), CD electrokinetic chromatography (CDEKC), micellar EKC (MEKC), CD-modified micellar electrokinetic chromatography (CD-MEKC), capillary electrochromatography (CEC), ligand-exchange CE (LE-CE), and nonaqueous CE (NACE) have been employed to the chiral analysis of amino acids. More than 160 published research articles collected from SciFinder Scholar databases from the year 2001 described the enantioseparations of amino acids by capillary-based electrophoresis. This review provides a comprehensive table listing the CE analysis of amino acid enantiomers with categorizing by the separation modes. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码：3078 / 3095
页数：18
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