A Single-Nucleotide Polymorphism in the Osteopontin Gene 9250 Contribute to Susceptibility to Ankylosing Spondylitis

被引：0

作者：

Tian, Peng ^{[1
]}

Zhang, Zhaoqing ^{[2
]}

Liu, Qiaomei ^{[2
]}

机构：

[1] Yichang Yiling Hosp, Dept Orthoped, Yichang 443100, Hubei Province, Peoples R China

[2] Third Hosp Wuhan, Dept Rehabil & Pain, Wuhan 430061, Hubei Province, Peoples R China

来源：

PAKISTAN JOURNAL OF ZOOLOGY | 2016年 / 48卷 / 06期

关键词：

Ankylosing spondylitis; Osteopontin; single nucleotide polymorphism; Susceptibility; SYSTEMIC-LUPUS-ERYTHEMATOSUS; ASSOCIATION; POPULATION; EXPRESSION; BONE;

D O I：

暂无

中图分类号：

Q95 [动物学];

学科分类号：

071002 ;

摘要：

The aim of this study was to investigate possible association of a single nucleotide polymorphism (SNP) at position 9250 in exon 7 of the Osteopontin gehe (OPN gene 9250) with ankylosing spondylitis (AS). A case control association study was performed in 120 AS patients and 106 matched controls, consented to participate in the study. OPN gene 9250 polymorphism was detected by polymerase chain reaction (PCR) and direct sequencing. The frequency of the TC+CC genotype of the OPN gene 9250 was significantly higher (25.83% vs 12.26%, p < 0.05) and the frequency of C allele was significantly higher (17.50% vs 8.96%, p < 0.01) in AS patients than in controls. There were significant differences in OPN gene 9250 allele and phenotype frequencies between the AS patients and controls (p < 0.05). OPN gene 9250 polymorphism appears to be associated with susceptibility to AS in Chinese patients.

引用

页码：1753 / 1756

页数：4

共 50 条

[41] A single-nucleotide polymorphism of the TNFAIP3 gene is associated with systemic lupus erythematosus in Chinese Han population [J].

Cai, Li-Qiong ;

Wang, Zai-Xing ;

Lu, Wen-Sheng ;

Han, Jian-Wen ;

Sun, Liang-Dan ;

Du, Wen-Hui ;

Zhang, Shu-Mei ;

Zuo, Xian-Bo ;

Zhang, Xue-Jun ;

Yang, Sen .

MOLECULAR BIOLOGY REPORTS, 2010, 37 (01) :389-394

[42] Association of single nucleotide polymorphism at position -308 of the tumor necrosis factor-alpha gene with ankylosing spondylitis and rheumatoid arthritis [J].

Manolova, Irena ;

Ivanova, Mariana ;

Stoilov, Rumen ;

Rashkov, Rasho ;

Stanilova, Spaska .

BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT, 2014, 28 (06) :1108-1114

[43] Thirteen single-nucleotide polymorphisms in the human osteopontin gene identified by sequencing of the entire gene in Japanese individuals [J].

Iwasaki, H ;

Shinohara, Y ;

Ezura, Y ;

Ishida, R ;

Kodaira, M ;

Kajita, M ;

Nakajima, T ;

Shiba, T ;

Emi, M .

JOURNAL OF HUMAN GENETICS, 2001, 46 (09) :544-546

[44] A CARD9 single-nucleotide polymorphism rs4077515 is associated with reduced susceptibility to and severity of primary immune thrombocytopenia [J].

Sheng, Zi ;

Li, Ju ;

Wang, Yuanjian ;

Li, Song ;

Hou, Ming ;

Peng, Jun ;

Feng, Qi .

ANNALS OF HEMATOLOGY, 2019, 98 (11) :2497-2506

[45] RETRACTED ARTICLE: Genetic variations in the KIR gene family may contribute to susceptibility to ankylosing spondylitis: a meta-analysis [J].

Hai-Ning Zuo ;

Zhi-Long Wang ;

Dao-Ran Cui ;

Da-Jiang Xin .

Molecular Biology Reports, 2014, 41 :5311-5319

[46] Association between vitamin D receptor gene polymorphism and ankylosing spondylitis in Han Chinese [J].

Zhang, Pingping ;

Li, Qiuxia ;

Qi, Jun ;

Lv, Qing ;

Zheng, Xuqi ;

Wu, Xinyu ;

Gu, Jieruo .

INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES, 2017, 20 (10) :1510-1516

[47] The adiponectin gene single-nucleotide polymorphism rs1501299 is associated with hepatocellular carcinoma risk [J].

X. Cai ;

Y. Gan ;

Y. Fan ;

J. Hu ;

Y. Jin ;

F. Chen ;

T. Chen ;

Y. Sun ;

J. Wang ;

W. Qin ;

Hong Tu .

Clinical and Translational Oncology, 2014, 16 :166-172

[48] The adiponectin gene single-nucleotide polymorphism rs1501299 is associated with hepatocellular carcinoma risk [J].

Cai, X. ;

Gan, Y. ;

Fan, Y. ;

Hu, J. ;

Jin, Y. ;

Chen, F. ;

Chen, T. ;

Sun, Y. ;

Wang, J. ;

Qin, W. ;

Tu, Hong .

CLINICAL & TRANSLATIONAL ONCOLOGY, 2014, 16 (02) :166-172

[49] Contribution of protein Z gene single-nucleotide polymorphism to systemic lupus erythematosus in Egyptian patients [J].

Yousry, Sherif M. ;

Shahin, Rasha M. H. ;

El Refai, Rasha M. .

BLOOD COAGULATION & FIBRINOLYSIS, 2016, 27 (06) :691-695

[50] Relationship between single-nucleotide polymorphism of matrix metalloproteinase-2 gene and colorectal cancer and gastric cancer susceptibility: a meta-analysis [J].

Wu, Zesheng ;

Jiang, Peng ;

Zulqarnain, Haider ;

Gao, Hua ;

Zhang, Wenbin .

ONCOTARGETS AND THERAPY, 2015, 8 :861-869

← 1 2 3 4 5 →