Parental Occupational Exposure and Neurodevelopmental Disorders in Offspring: a Systematic Review and Meta-analysis

被引：15

作者：

Bemanalizadeh, Maryam ^{[1
]}

Khoshhali, Mehri ^{[1
]}

Goli, Parvin ^{[1
]}

Abdollahpour, Ibrahim ^{[1
]}

Kelishadi, Roya ^{[1
]}

机构：

[1] Isfahan Univ Med Sci, Child Growth & Dev Res Ctr, Res Inst Primordial Prevent Noncommunicable Dis, Esfahan, Iran

来源：

CURRENT ENVIRONMENTAL HEALTH REPORTS | 2022年 / 9卷 / 03期

关键词：

Neurodevelopmental disorders; Autism spectrum disorder; Attention deficit disorder with hyperactivity; Communication disorders; Motor skills disorders; Learning disabilities; Intellectual disability; Occupational exposure; Maternal exposure; Paternal exposure; AUTISM SPECTRUM DISORDERS; PESTICIDE EXPOSURE; NEUROBEHAVIORAL DEFICITS; ORGANIC-SOLVENTS; AIR-POLLUTION; CHILDREN; PREGNANCY; ENVIRONMENT; RISK; ASTHMAGENS;

D O I：

10.1007/s40572-022-00356-6

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Purpose of Review Parental occupational exposures might be associated with neurodevelopmental disorders (NDDs) in offspring. We aimed to conduct a systematic review and meta-analysis to summarize and synthesize the current literature and to estimate the pooled magnitude of the underlying association(s) between parental occupational exposures and subsequent risk of NDDs. Recent Findings In the meta-analysis of 20 included studies, significant associations were found between parental occupational exposure to pesticides or solvents and the risk of attention deficit hyperactivity disorder in offspring. Prenatal occupational exposure to pesticides was significantly associated with motor development or cognition disorders in children. Furthermore, some evidence showed that metals might have a role in the development of autism spectrum disorders. Further studies need to identify the level of parental occupational exposures that can be significantly associated with NDDs. Moreover, utilizing standardized outcome and exposure scales is recommended to incorporate paternal, maternal, and parental as well as both prenatal and postnatal exposure in future studies.

引用

页码：406 / 422

页数：17

共 73 条

[1] Occupational pesticide exposure in early pregnancy associated with sex-specific neurobehavioral deficits in the children at school age [J].