The Confluence of Stereotactic Ablative Radiotherapy and Tumor Immunology

被引:134
作者
Finkelstein, Steven Eric [1 ]
Timmerman, Robert [2 ]
McBride, WilliamH. [3 ]
Schaue, Doerthe [3 ]
Hoffe, Sarah E. [4 ]
Mantz, Constantine A. [1 ]
Wilson, George D. [5 ]
机构
[1] 21st Century Oncol Translat Res Consortium, Scottsdale, AZ 85251 USA
[2] Univ Texas SW Med Ctr Dallas, Dept Radiat Oncol & Neurol Surg, Dallas, TX 75391 USA
[3] Univ Calif Los Angeles, David Geffen Sch Med, Dept Radiat Oncol, Los Angeles, CA 90095 USA
[4] Moffitt Int, Dept Radiat Oncol, Tampa, FL 33612 USA
[5] William Beaumont Hosp, Div Radiat Biol, Royal Oak, MI 48073 USA
来源
CLINICAL & DEVELOPMENTAL IMMUNOLOGY | 2011年
关键词
LINEAR-QUADRATIC MODEL; CD8(+) T-CELLS; RADIATION-THERAPY; LOCAL RADIATION; CANCER-PATIENTS; BREAST-CANCER; FRACTION; RADIOSURGERY; IRRADIATION; IMMUNOTHERAPY;
D O I
10.1155/2011/439752
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Stereotactic radiation approaches are gaining more popularity for the treatment of intracranial as well as extracranial tumors in organs such as the liver and lung. Technology, rather than biology, is driving the rapid adoption of stereotactic body radiation therapy (SBRT), also known as stereotactic ablative radiotherapy (SABR), in the clinic due to advances in precise positioning and targeting. Dramatic improvements in tumor control have been demonstrated; however, our knowledge of normal tissue biology response mechanisms to large fraction sizes is lacking. Herein, we will discuss how SABR can induce cellular expression of MHC I, adhesion molecules, costimulatory molecules, heat shock proteins, inflammatory mediators, immunomodulatory cytokines, and death receptors to enhance antitumor immune responses.
引用
收藏
页数:7
相关论文
共 50 条
[1]   Influence of bone marrow-derived hematopoietic cells on the tumor response to radiotherapy Experimental models and clinical perspectives [J].
Ahn, G-One ;
Brown, J. Martin .
CELL CYCLE, 2009, 8 (07) :970-976
[2]   Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy [J].
Apetoh, Lionel ;
Ghiringhelli, Francois ;
Tesniere, Antoine ;
Obeid, Michel ;
Ortiz, Carla ;
Criollo, Alfredo ;
Mignot, Gregoire ;
Maiuri, M. Chiara ;
Ullrich, Evelyn ;
Saulnier, Patrick ;
Yang, Huan ;
Amigorena, Sebastian ;
Ryffel, Bernard ;
Barrat, Franck J. ;
Saftig, Paul ;
Levi, Francis ;
Lidereau, Rosette ;
Nogues, Catherine ;
Mira, Jean-Paul ;
Chompret, Agnes ;
Joulin, Virginie ;
Clavel-Chapelon, Francoise ;
Bourhis, Jean ;
Andre, Fabrice ;
Delaloge, Suzette ;
Tursz, Thomas ;
Kroemer, Guido ;
Zitvogel, Laurence .
NATURE MEDICINE, 2007, 13 (09) :1050-1059
[3]   The linear-quadratic model is an appropriate methodology for determining isoeffective doses at large doses per fraction [J].
Brenner, David J. .
SEMINARS IN RADIATION ONCOLOGY, 2008, 18 (04) :234-239
[4]   External beam radiation of tumors alters phenotype of tumor cells to render them susceptible to vaccine-mediated T-cell killing [J].
Chakraborty, M ;
Abrams, SI ;
Coleman, CN ;
Camphausen, K ;
Schlom, J ;
Hodge, JW .
CANCER RESEARCH, 2004, 64 (12) :4328-4337
[5]   Radiotherapy Decreases Vascular Density and Causes Hypoxia with Macrophage Aggregation in TRAMP-C1 Prostate Tumors [J].
Chen, Fang-Hsin ;
Chiang, Chi-Shiun ;
Wang, Chun-Chieh ;
Tsai, Chien-Sheng ;
Jung, Shih-Ming ;
Lee, Chung-Chi ;
McBride, William H. ;
Hong, Ji-Hong .
CLINICAL CANCER RESEARCH, 2009, 15 (05) :1721-1729
[6]   RADIATION ENHANCES TUMOR-NECROSIS-FACTOR-ALPHA PRODUCTION BY MURINE BRAIN-CELLS [J].
CHIANG, CS ;
MCBRIDE, WH .
BRAIN RESEARCH, 1991, 566 (1-2) :265-269
[7]   HIGH DOSE PER-FRACTION IRRADIATION OF LIMITED LUNG VOLUMES USING AN IMAGE-GUIDED, HIGHLY FOCUSED IRRADIATOR: SIMULATING STEREOTACTIC BODY RADIOTHERAPY REGIMENS IN A SMALL-ANIMAL MODEL [J].
Cho, Jaeho ;
Kodym, Reinhard ;
Seliounine, Serguei ;
Richardson, James A. ;
Solberg, Timothy D. ;
Story, Michael D. .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2010, 77 (03) :895-902
[8]  
Demaria S, 2005, CLIN CANCER RES, V11, P728
[9]   Fractionated but Not Single-Dose Radiotherapy Induces an Immune-Mediated Abscopal Effect when Combined with Anti-CTLA-4 Antibody [J].
Dewan, M. Zahidunnabi ;
Galloway, Ashley E. ;
Kawashima, Noriko ;
Dewyngaert, J. Keith ;
Babb, James S. ;
Formenti, Silvia C. ;
Demaria, Sandra .
CLINICAL CANCER RESEARCH, 2009, 15 (17) :5379-5388
[10]   Cancer immunoediting: from immunosurveillance to tumor escape [J].
Dunn, GP ;
Bruce, AT ;
Ikeda, H ;
Old, LJ ;
Schreiber, RD .
NATURE IMMUNOLOGY, 2002, 3 (11) :991-998