Expanding the accessible chemical space by solid phase synthesis of bicyclic homodetic peptides

被引：20
作者：
Bartoloni, Marco [1 ]
Kadam, Rameshwar U. [1 ]
Schwartz, Julian [1 ]
Furrer, Julien [1 ]
Darbre, Tamis [1 ]
Reymond, Jean-Louis [1 ]
机构：
[1] Univ Bern, Dept Chem & Biochem, CH-3012 Bern, Switzerland
来源：
CHEMICAL COMMUNICATIONS | 2011年 / 47卷 / 47期
基金：
瑞士国家科学基金会;
关键词：
COMBINATORIAL LIBRARIES; RIBOSOMAL SYNTHESIS; DESIGN; RECEPTORS; ANTAGONIST; STRATEGIES; MIMETICS; PROGRESS; SYSTEM; DRUGS;
D O I：
10.1039/c1cc15704c
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Norbornapeptides (bicyclo[2.2.1]heptapeptides) and related bicyclic homodetic peptides were prepared by solid-phase peptide synthesis using an orthogonal protection scheme. These conformationally rigid peptides cover an almost pristine area of peptide topological space and adopt globular shapes similar to those of short alpha-helical peptides.
引用
收藏
页码：12634 / 12636
页数：3
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