Intramolecular nucleophilic activation promoting efficient hydrolytic cleavage of DNA by (aqua)bis-(dipyridoquinoxaline)copper(II) complex

被引：80

作者：

Dhar, S ^{[1
]}

Reddy, PAN ^{[1
]}

Chakravarty, AR ^{[1
]}

机构：

[1] Indian Inst Sci, Dept Inorgan & Phys Chem, Bangalore 560012, Karnataka, India

来源：

DALTON TRANSACTIONS | 2004年 / 05期

关键词：

D O I：

10.1039/b401383b

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The axial aqua bound copper(II) complex [Cu(dpq)(2)(H2O)](ClO4)(2), having a planar NN-donor heterocyclic base dipyridoquinoxaline (dpq) as the DNA minor groove binder, shows efficient hydrolytic cleavage of supercoiled DNA in the dark and in the absence of any external reagents, as evidenced from T4 ligase experiments, with a rate of 5.58+/-0.4 h(-1) and a rate enhancement of 1.55x10(8).

引用

页码：697 / 698

页数：2

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