Background: The current health situation is causing a detriment to mental health, where pri-mary care physicians is a very affected group.Objective: The objective is to discover whether the resilience variable is a predictor of the negative impact generated by COVID-19, understood in the variables of depression, anxiety and stress; and analyze, in turn, which resilient factors help to explain the variances of the variables and which control variables are also predictors. Method: A quantitative research has been carried out, specifically a single group non -experimental ex post facto design. The selected sample consisted of 268 primary care physicians, a group highly affected by the pandemic, who were administered a sociodemo-graphic questionnaire, the SV-RES Resilience Scale, in its reduced version of 36 items, and the Depression, Anxiety and Depression Scale, DAS-21 stress.Results: The results of the linear regressions showed how resilience, with a negative relations-hip, predicts depression (22.2%), anxiety (8.3%) and stress (12.3%), being the goals and identity factors that contribute significantly to explain the different variances. In turn, within the con-trol variables, taking drugs, gender (except for the depression variable) and the decision to go to the psychologist were predictors of the various variables.Conclusions: The findings of this research intensify the necessity of promoting resilience among primary care physicians, with the intention of reducing their levels of depression, anxiety, and stress.(c) 2022 Sociedad Espanola de Medicos de Atencion Primaria (SEMERGEN). Published by Elsevier Espana, S.L.U. All rights reserved.