Time and cost effective production of sodium [18F]fluoride using a dedicated automation module with disposable cassettes for GMP environment

被引：1

作者：

Choi, Jae Yong ^{[1
]}

Lee, Ji Woong ^{[2
]}

Lee, Kyo Chul ^{[2
]}

Kim, Kyeong Min ^{[2
]}

Seo, Youngbeom ^{[1
]}

Kim, Jung Young ^{[2
]}

Ryu, Young Hoon ^{[1
]}

机构：

[1] Yonsei Univ, Coll Med, Gangnam Severance Hosp, Dept Nucl Med, Seoul, South Korea

[2] Korea Inst Radiol & Med Sci, Mol Imaging Res Ctr, Seoul, South Korea

来源：

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY | 2016年 / 309卷 / 03期

关键词：

Sodium [F-18]fluoride; Bone scintigraphy; Positron emission tomography; BONE METASTASES; TARGET; RADIOACTIVITY; IMPURITIES;

D O I：

10.1007/s10967-016-4709-5

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The aim of the present study is to establish a time and cost effective Na[F-18]F preparation method. The process is composed of absorbing radioactive impurities with cation exchange cartridge (CM), trapping F-18-fluroide with QMA cartridges, and formulating the product. The total preparation time determined at the end of bombardment was 4 min and the radiochemical yield was 82 % (n = 29). The final formulated Na[F-18]F solution satisfies the USP criteria for quality control.

引用

页码：983 / 987

页数：5

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