'Til cell death do us part: nitric oxide and mechanisms of hepatotoxicity

被引:13
作者
Kim, PKM
Zuckerbraun, BS
Otterbein, LE
Vodovotz, Y
Billiar, TR
机构
[1] Univ Pittsburgh, Sch Med, Dept Surg, Pittsburgh, PA 15213 USA
[2] Univ Pittsburgh, Sch Med, Div Pulm & Crit Care Med, Pittsburgh, PA 15213 USA
关键词
apoptosis; carbon monoxide; caspase; cGMP; FADD; heme oxygenase; hepatocyte; liver; necrosis; nitric oxide; nitric oxide synthase;
D O I
10.1515/BC.2004.002
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Like many juggernauts in biology, the elusive nature of nitric oxide (NO) sprints through the fields, sometimes the savior, at other times the scimitar. In the liver, which is the metabolic center of the organism, hepatocytes and immune cells trade blows using the reactive diatomic molecule NO to induce cellular damage under toxic conditions. In response, hepatocytes can utilize several mechanisms of NO to their protective advantage by prohibiting the activation of programmed cell death, a.k.a. apoptosis. The balance of these effects in this reactive milieu set the stage for the homeostatic response to cellular injury that determines whether hepatocytes will live, die, or regenerate. Insights that we and others have gained from the liver under pathologic conditions of stress can be applied to the understanding of cellular death mechanisms in other organs and tissues.
引用
收藏
页码:11 / 15
页数:5
相关论文
共 58 条
  • [1] The effect of nitric oxide on cell respiration:: A key to understanding its role in cell survival or death
    Beltrán, B
    Mathur, A
    Duchen, MR
    Erusalimsky, JD
    Moncada, S
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (26) : 14602 - 14607
  • [2] Inhibition of mitochondrial respiration by endogenous nitric oxide:: A critical step in Fas signaling
    Beltrán, B
    Quintero, M
    García-Zaragozá, E
    O'Connor, E
    Esplugues, JV
    Moncada, S
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (13) : 8892 - 8897
  • [3] Regulation of transglutaminases by nitric oxide
    Bernassola, F
    Rossi, A
    Melino, G
    [J]. MECHANISMS OF CELL DEATH: THE SECOND ANNUAL CONFERENCE OF THE CELL DEATH SOCIETY, 1999, 887 : 83 - 91
  • [4] NITRIC-OXIDE - NOVEL BIOLOGY WITH CLINICAL RELEVANCE
    BILLIAR, TR
    [J]. ANNALS OF SURGERY, 1995, 221 (04) : 339 - 349
  • [5] Nitric oxide-mediated cytoprotection of hepatocytes from glucose deprivation-induced cytotoxicity: Involvement of heme oxygenase-1
    Choi, BM
    Pae, HO
    Kim, YM
    Chung, HT
    [J]. HEPATOLOGY, 2003, 37 (04) : 810 - 823
  • [6] Nitric oxide as a bioregulator of apoptosis
    Chung, HT
    Pae, HO
    Choi, BM
    Billiar, TR
    Kim, YM
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2001, 282 (05) : 1075 - 1079
  • [7] Persistent inhibition of cell respiration by nitric oxide:: Crucial role of S-nitrosylation of mitochondrial complex I and protective action of glutathione
    Clementi, E
    Brown, GC
    Feelisch, M
    Moncada, S
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (13) : 7631 - 7636
  • [8] Nitric oxide inhibits tumor necrosis factor-α-induced apoptosis by reducing the generation of ceramide
    De Nadai, C
    Sestili, P
    Cantoni, O
    Lièvremont, JP
    Sciorati, C
    Barsacchi, R
    Moncada, S
    Meldolesi, J
    Clementi, E
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (10) : 5480 - 5485
  • [9] Dimmeler S, 1998, CELL GROWTH DIFFER, V9, P415
  • [10] NITRIC-OXIDE SYNTHASE ISOZYMES - CHARACTERIZATION, PURIFICATION, MOLECULAR-CLONING, AND FUNCTIONS
    FORSTERMANN, U
    CLOSS, EI
    POLLOCK, JS
    NAKANE, M
    SCHWARZ, P
    GATH, I
    KLEINERT, H
    [J]. HYPERTENSION, 1994, 23 (06) : 1121 - 1131